Nutf2 - nuclear transport factor 2 Gene

Rattus norvegicus

Also known as NTF2

Gene ID: 291981 | Gene type: protein coding

About Nutf2

Summary

Enables nuclear import signal receptor activity and small GTPase binding activity. Involved in negative regulation of vascular endothelial growth factor production; positive regulation of protein import into nucleus; and protein localization to nucleus. Located in cytosol and nuclear outer membrane. Part of nuclear pore central transport channel. Used to study diabetic retinopathy. Orthologous to human NUTF2 (nuclear transport factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Nutf2 Products(1)

mRNA	Protein	Name
NM_001007629.2	NP_001007630.1	nuclear transport factor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear import signal receptor activity	IDA IDA: Inferred from direct assay	9822603	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8707840	RGD
enables small GTPase binding	IPI IPI: Inferred from physical interaction	8918934	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of vascular endothelial growth factor production	IMP IMP: Inferred from mutant phenotype	19404486	RGD
involved in positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	9368653	RGD
involved in protein import into nucleus	IMP IMP: Inferred from mutant phenotype	9822603	RGD
involved in protein localization to nuclear pore	IMP IMP: Inferred from mutant phenotype	10543952	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	9822603	RGD
located in nuclear membrane	IDA IDA: Inferred from direct assay	9822603	RGD
located in nuclear outer membrane	IDA IDA: Inferred from direct assay	10543952	RGD
part of nuclear pore central transport channel	IDA IDA: Inferred from direct assay	10543952	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear transport factor 2

NTF-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09705	NUTF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nutf2	NCBI	NCBI:10204

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