Nutf2 - nuclear transport factor 2 Gene

Also Known as NTF2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 291981

Summary

Enables nuclear import signal receptor activity and small GTPase binding activity. Involved in negative regulation of vascular endothelial growth factor production; positive regulation of protein import into nucleus; and protein localization to nucleus. Located in cytosol and nuclear outer membrane. Part of nuclear pore central transport channel. Used to study diabetic retinopathy. Orthologous to human NUTF2 (nuclear transport factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Nutf2 Products (1)

mRNA Protein Name
NM_001007629.2 NP_001007630.1 nuclear transport factor 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear import signal receptor activity IDA
IDA: Inferred from direct assay
9822603 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
8707840 RGD
enables small GTPase binding IPI
IPI: Inferred from physical interaction
8918934 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of vascular endothelial growth factor production IMP
IMP: Inferred from mutant phenotype
19404486 RGD
involved in positive regulation of protein import into nucleus IMP
IMP: Inferred from mutant phenotype
9368653 RGD
involved in protein import into nucleus IMP
IMP: Inferred from mutant phenotype
9822603 RGD
involved in protein localization to nuclear pore IMP
IMP: Inferred from mutant phenotype
10543952 RGD
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
9822603 RGD
located in nuclear membrane IDA
IDA: Inferred from direct assay
9822603 RGD
located in nuclear outer membrane IDA
IDA: Inferred from direct assay
10543952 RGD
part of nuclear pore central transport channel IDA
IDA: Inferred from direct assay
10543952 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear transport factor 2

  • NTF-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09705 NUTF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nutf2 NCBI NCBI:10204