Adcy8 - adenylate cyclase 8 Gene

Also Known as Ac8

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29241

Summary

Enables several functions, including calcium- and calmodulin-responsive Adenylate Cyclase activity; Calmodulin binding activity; and protein dimerization activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular chemical homeostasis; and cellular response to organonitrogen compound. Located in several cellular components, including caveola; clathrin-coated pit; and neuronal cell body membrane. Colocalizes with actin Cytoskeleton. Orthologous to human ADCY8 (Adenylate Cyclase 8). [provided by Alliance of Genome Resources, Apr 2022]

Adcy8 Products (1)

mRNA Protein Name
NM_017142.1 NP_058838.1 adenylate cyclase type 8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
22399809 RGD
enables calcium- and calmodulin-responsive adenylate cyclase activity IDA
IDA: Inferred from direct assay
8163524 RGD
enables calmodulin binding IDA
IDA: Inferred from direct assay
16258073 RGD
enables phosphatase binding IPI
IPI: Inferred from physical interaction
16258073 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
20410303 RGD
enables protein dimerization activity IDA
IDA: Inferred from direct assay
19158400 RGD
enables protein heterodimerization activity IMP
IMP: Inferred from mutant phenotype
11856299 RGD
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
11856299 RGD
enables protein phosphatase 2A binding IDA
IDA: Inferred from direct assay
22976297 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled opioid receptor signaling pathway IDA
IDA: Inferred from direct assay
16186630 RGD
involved in activation of protein kinase A activity IMP
IMP: Inferred from mutant phenotype
25381556 RGD
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21046358 RGD
involved in cAMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
16741924 RGD
involved in cAMP/PKA signal transduction IDA
IDA: Inferred from direct assay
8163524 RGD
involved in cellular response to calcium ion IDA
IDA: Inferred from direct assay
19158400 RGD
involved in cellular response to calcium ion IMP
IMP: Inferred from mutant phenotype
19305019 RGD
involved in cellular response to forskolin IDA
IDA: Inferred from direct assay
13680124 RGD
involved in cellular response to glucagon stimulus IMP
IMP: Inferred from mutant phenotype
21046358 RGD
involved in cellular response to glucose stimulus IDA
IDA: Inferred from direct assay
21046358 RGD
involved in cellular response to morphine IDA
IDA: Inferred from direct assay
16186630 RGD
involved in glucose mediated signaling pathway IDA
IDA: Inferred from direct assay
13680124 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
21046358 RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
21046358 RGD
involved in protein complex oligomerization IDA
IDA: Inferred from direct assay
19158400 RGD
involved in protein homooligomerization IMP
IMP: Inferred from mutant phenotype
11856299 RGD
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
22399809 RGD
located in caveola IDA
IDA: Inferred from direct assay
11744699 RGD
located in clathrin-coated pit IDA
IDA: Inferred from direct assay
19158400 RGD
located in dendrite IDA
IDA: Inferred from direct assay
16258073 RGD
located in membrane raft IDA
IDA: Inferred from direct assay
16258073 RGD
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
16258073 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
13680124 RGD
located in plasma membrane raft IDA
IDA: Inferred from direct assay
19171672 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adenylate cyclase type 8

  • ATP pyrophosphate-lyase 8

  • adenylate cyclase 8 (brain)

  • adenylate cyclase type VIII

  • adenylyl cyclase 8

  • ca(2+)/calmodulin-activated adenylyl cyclase

  • type VIII adenylyl cyclase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00334 ADCY8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adcy8 NCBI NCBI:114