Adcy8 - adenylate cyclase 8 Gene

Rattus norvegicus

Also known as Ac8

Gene ID: 29241 | Gene type: protein coding

About Adcy8

Summary

Enables several functions, including calcium- and calmodulin-responsive Adenylate Cyclase activity; Calmodulin binding activity; and protein dimerization activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular chemical homeostasis; and cellular response to organonitrogen compound. Located in several cellular components, including caveola; clathrin-coated pit; and neuronal cell body membrane. Colocalizes with actin Cytoskeleton. Orthologous to human ADCY8 (Adenylate Cyclase 8). [provided by Alliance of Genome Resources, Apr 2022]

Adcy8 Products(1)

mRNA	Protein	Name
NM_017142.1	NP_058838.1	adenylate cyclase type 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IDA IDA: Inferred from direct assay	22399809	RGD
enables calcium- and calmodulin-responsive adenylate cyclase activity	IDA IDA: Inferred from direct assay	8163524	RGD
enables calmodulin binding	IDA IDA: Inferred from direct assay	16258073	RGD
enables phosphatase binding	IPI IPI: Inferred from physical interaction	16258073	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	20410303	RGD
enables protein dimerization activity	IDA IDA: Inferred from direct assay	19158400	RGD
enables protein heterodimerization activity	IMP IMP: Inferred from mutant phenotype	11856299	RGD
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11856299	RGD
enables protein phosphatase 2A binding	IDA IDA: Inferred from direct assay	22976297	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled opioid receptor signaling pathway	IDA IDA: Inferred from direct assay	16186630	RGD
involved in activation of protein kinase A activity	IMP IMP: Inferred from mutant phenotype	25381556	RGD
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21046358	RGD
involved in cAMP biosynthetic process	IMP IMP: Inferred from mutant phenotype	16741924	RGD
involved in cAMP/PKA signal transduction	IDA IDA: Inferred from direct assay	8163524	RGD
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	19158400	RGD
involved in cellular response to calcium ion	IMP IMP: Inferred from mutant phenotype	19305019	RGD
involved in cellular response to forskolin	IDA IDA: Inferred from direct assay	13680124	RGD
involved in cellular response to glucagon stimulus	IMP IMP: Inferred from mutant phenotype	21046358	RGD
involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	21046358	RGD
involved in cellular response to morphine	IDA IDA: Inferred from direct assay	16186630	RGD
involved in glucose mediated signaling pathway	IDA IDA: Inferred from direct assay	13680124	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	21046358	RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	21046358	RGD
involved in protein complex oligomerization	IDA IDA: Inferred from direct assay	19158400	RGD
involved in protein homooligomerization	IMP IMP: Inferred from mutant phenotype	11856299	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	22399809	RGD
located in caveola	IDA IDA: Inferred from direct assay	11744699	RGD
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	19158400	RGD
located in dendrite	IDA IDA: Inferred from direct assay	16258073	RGD
located in membrane raft	IDA IDA: Inferred from direct assay	16258073	RGD
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	16258073	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	13680124	RGD
located in plasma membrane raft	IDA IDA: Inferred from direct assay	19171672	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

adenylate cyclase type 8

ATP pyrophosphate-lyase 8	adenylate cyclase 8 (brain)
adenylate cyclase type VIII	adenylyl cyclase 8
ca(2+)/calmodulin-activated adenylyl cyclase	type VIII adenylyl cyclase

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00334	ADCY8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adcy8	NCBI	NCBI:114

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