2. Gene
  3. ADCY8 - adenylate cyclase 8 Gene

ADCY8 - adenylate cyclase 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AC8; ADCY3; HBAC1

Gene ID: 114 | Gene type: protein coding

About ADCY8

Cytogenetic location: 8q24.22 Genomic coordinates (GRCh38): 8:130,780,301-131,040,909 (from NCBI)

This gene has 3 transcripts (splice variants), 197 orthologues and 17 paralogues. Biased expression in brain (RPKM 4.1), lung (RPKM 0.8) and 2 other tissues.

Summary

Adenylate Cyclase is a membrane bound Enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several Hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]

ADCY8 Products(1)

mRNA Protein Name
NM_001115.3 NP_001106.1 adenylate cyclase type 8

ADCY8 Protein Structure

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (406 - 588)

DUF1053

DUF1053: Domain of Unknown Function (DUF1053) (618 - 712)

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (974 - 1171)

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  • 1251 a.a.
Protein Preferred Names Protein Names

adenylate cyclase type 8

ATP pyrophosphate-lyase 8

Related Diseases

Diseases Alias
Dissociative Amnesia

Psychogenic Amnesia

Amnesia, Dissociative

Amnesia, Psychogenic

Amnesia Neurosis

Hysterical Fugue

Dissociative Fugue
Joubert Syndrome 24

JBTS24
Nemaline Myopathy 7

NEM7

Nemaline Myopathy 7, Autosomal Recessive

Cfl2-Related Nemaline Myopathy

Myopathy, Nemaline, Type 7
Dissociative Disorder

Dissociative Disorders

Dissociative Disease

Dissociative Reaction
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00334 ADCY8 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ADCY8 MGD MGI:1341110
Canis familiaris ADCY8 VGNC VGNC:37625
Felis catus ADCY8 VGNC VGNC:59621
Rattus norvegicus ADCY8 RGD RGD:2036
Macaca mulatta ADCY8 VGNC VGNC:69516
Bos taurus ADCY8 VGNC VGNC:25649