Nelfe - negative elongation factor complex member E Gene

Rattus norvegicus

Also known as Rd; Rdbp

Gene ID: 294258 | Gene type: protein coding

About Nelfe

Summary

Enables chromatin binding activity. Involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of histone H3-K4 methylation; and regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human NELFE (negative elongation factor complex member E). [provided by Alliance of Genome Resources, Apr 2022]

Nelfe Products(2)

mRNA	Protein	Name
NM_001165901.1	NP_001159373.1	negative elongation factor E
NM_212548.2	NP_997713.1	negative elongation factor E

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	20097260	RGD
enables chromatin binding	IMP IMP: Inferred from mutant phenotype	21623364	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20097260	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	19014935	RGD
involved in positive regulation of protein modification process	IMP IMP: Inferred from mutant phenotype	21623364	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21623364	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

negative elongation factor E

RD RNA-binding protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09203	NELFE Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nelfe	NCBI	NCBI:7936

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