Coro1b - coronin 1B Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29474

Summary

Enables Arp2/3 complex binding activity and cytoskeletal protein binding activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; negative regulation of lamellipodium morphogenesis; and negative regulation of smooth muscle cell chemotaxis. Located in several cellular components, including lamellipodium; perinuclear region of cytoplasm; and stress fiber. Orthologous to human CORO1B (coronin 1B). [provided by Alliance of Genome Resources, Apr 2022]

Coro1b Products (1)

mRNA Protein Name
NM_019222.2 NP_062095.2 coronin-1B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Arp2/3 complex binding IPI
IPI: Inferred from physical interaction
18775315 RGD
enables cytoskeletal protein binding IPI
IPI: Inferred from physical interaction
22619279 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
17350576 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to platelet-derived growth factor stimulus IDA
IDA: Inferred from direct assay
22619279 RGD
involved in cellular response to platelet-derived growth factor stimulus IMP
IMP: Inferred from mutant phenotype
22619279 RGD
involved in negative regulation of lamellipodium morphogenesis IMP
IMP: Inferred from mutant phenotype
22619279 RGD
involved in negative regulation of smooth muscle cell chemotaxis IMP
IMP: Inferred from mutant phenotype
22619279 RGD
involved in protein kinase C signaling IDA
IDA: Inferred from direct assay
16027158 RGD
Cellular Component GO Annotation Evidence References Source
located in cell leading edge IDA
IDA: Inferred from direct assay
16027158 RGD
located in cell periphery IDA
IDA: Inferred from direct assay
22619279 RGD
located in cytosol IDA
IDA: Inferred from direct assay
22619279 RGD
located in lamellipodium IDA
IDA: Inferred from direct assay
22619279 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
22619279 RGD
located in stress fiber IDA
IDA: Inferred from direct assay
22619279 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

coronin-1B

  • coronin, actin-binding protein, 1B

  • coronin-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03049 CORO1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Coro1b NCBI NCBI:57175