Slc22a3 - solute carrier family 22 member 3 Gene

Rattus norvegicus

Gene ID: 29504 | Gene type: protein coding

About Slc22a3

Summary

Enables ion transmembrane transporter activity and toxin transmembrane transporter activity. Involved in cation transport; organic anion transport; and quaternary ammonium group transport. Predicted to be located in neuronal cell body and plasma membrane. Orthologous to human SLC22A3 (solute carrier family 22 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc22a3 Products(1)

mRNA	Protein	Name
NM_019230.1	NP_062103.1	solute carrier family 22 member 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables dopamine:sodium symporter activity	IDA IDA: Inferred from direct assay	9830022	RGD
enables monoamine transmembrane transporter activity	IDA IDA: Inferred from direct assay	16581093	RGD
enables neurotransmitter transmembrane transporter activity	IDA IDA: Inferred from direct assay	16581093	RGD
enables organic anion transmembrane transporter activity	IDA IDA: Inferred from direct assay	20924140	RGD
enables organic cation transmembrane transporter activity	IDA IDA: Inferred from direct assay	9632645	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11238452	RGD
enables quaternary ammonium group transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	9632645	RGD
enables spermidine transmembrane transporter activity	IDA IDA: Inferred from direct assay	23458604	RGD
enables toxin transmembrane transporter activity	IDA IDA: Inferred from direct assay	9830022	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in dopamine transport	IDA IDA: Inferred from direct assay	9830022	RGD
involved in epinephrine transport	IDA IDA: Inferred from direct assay	16581093	RGD
involved in histamine transport	IDA IDA: Inferred from direct assay	16581093	RGD
involved in norepinephrine transport	IDA IDA: Inferred from direct assay	16581093	RGD
involved in organic anion transport	IDA IDA: Inferred from direct assay	20924140	RGD
involved in organic cation transport	IDA IDA: Inferred from direct assay	9632645	RGD
involved in quaternary ammonium group transport	IMP IMP: Inferred from mutant phenotype	9632645	RGD
involved in serotonin transport	IDA IDA: Inferred from direct assay	16581093	RGD
involved in spermidine transport	IDA IDA: Inferred from direct assay	23458604	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15817714	RGD
located in endomembrane system	IDA IDA: Inferred from direct assay	27659446	RGD
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	27659446	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	27659446	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

solute carrier family 22 member 3

organic cation transporter 3	solute carrier family 22 (extraneuronal monoamine transporter), member 3
solute carrier family 22 (organic cation transporter), member 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13074	SLC22A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc22a3	NCBI	NCBI:6581

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