Ighmbp2 - immunoglobulin mu DNA binding protein 2 Gene

Rattus norvegicus

Also known as AEP

Gene ID: 29532 | Gene type: protein coding

About Ighmbp2

Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including growth cone; neuronal cell body; and nuclear body. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2S and distal spinal muscular atrophy 1. Orthologous to human IGHMBP2 (immunoglobulin mu DNA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Ighmbp2 Products(1)

mRNA	Protein	Name
NM_031586.2	NP_113774.2	DNA-binding protein SMUBP-2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15358184	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15358184	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

DNA-binding protein SMUBP-2

ATP-dependent helicase IGHMBP2	antifreeze enhancer-binding protein ortholog
immunoglobulin S mu binding protein 2	immunoglobulin mu binding protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06638	IGHMBP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ighmbp2	NCBI	NCBI:3508

Name
Email *

	Sorry, but the email address you supplied was invalid.