Bag1 - BAG cochaperone 1 Gene

Also Known as Bag-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 297994

Summary

The oncogene Bcl2 encodes a membrane protein that blocks a step in a pathway leading to Apoptosis or programmed cell death. Studies in human and mouse suggest that the protein encoded by this gene (referred to as Bcl2-associated athanogene) binds to Bcl2 protein. It enhances the anti-apoptotic effects of Bcl2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least two protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) start site and an alternative, downstream, AUG translation initiation site. [provided by RefSeq, Jul 2008]

Bag1 Products (2)

mRNA Protein Name
NM_001106647.3 NP_001100117.2 BAG family molecular chaperone regulator 1 isoform 1L
NM_001256084.1 NP_001243013.1 BAG family molecular chaperone regulator 1 isoform 1S

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21808025 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17546604 RGD
involved in positive regulation of Schwann cell differentiation IMP
IMP: Inferred from mutant phenotype
23108487 RGD
involved in positive regulation of smooth muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
21808025 RGD
involved in response to benzene IEP
IEP: Inferred from expression pattern
18093815 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
15785859 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18093815 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
15872096 RGD
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17546604 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

BAG family molecular chaperone regulator 1

  • BCL2-associated athanogene

  • Bcl2 associated athanogene 1

  • bcl-2-associated athanogene 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124611 JG-231 98.47% Unkown
HY-124811 IRES-C11 Inhibitor 98.01% Unkown
HY-RS01342 BAG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bag1 NCBI NCBI:573