Srebf2 - sterol regulatory element binding transcription factor 2 Gene

Rattus norvegicus

Also known as SREBP2; SREBP-2; Srebf2_retired

Gene ID: 300095 | Gene type: protein coding

About Srebf2

Summary

Enables chromatin binding activity and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription, DNA-templated; response to lead ion; and spermatogenesis. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm; dendrite; and nucleus. Biomarker of kidney disease (multiple); lipid storage disease; obesity; and visual epilepsy. Human ortholog(s) of this gene implicated in carotid artery disease; prostate cancer; type 1 diabetes mellitus; type 2 diabetes mellitus; and vascular dementia. Orthologous to human SREBF2 (sterol regulatory element binding transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Srebf2 Products(1)

mRNA	Protein	Name
NM_001033694.2	NP_001028866.2	sterol regulatory element-binding protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	19470373	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12446768	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19470373	RGD
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12446768	RGD
involved in response to hormone	IMP IMP: Inferred from mutant phenotype	19470373	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	16705668	RGD
involved in response to lipid	IEP IEP: Inferred from expression pattern	17709436	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	11551527	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	16723505	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	19124072	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sterol regulatory element-binding protein 2

sterol regulatory element binding factor 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13758	SREBF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21946	Srebf2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-179526	Sino-C		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Srebf2	NCBI	NCBI:6721

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