2. Gene
  3. Sh3rf2 - SH3 domain containing ring finger 2 Gene

Sh3rf2 - SH3 domain containing ring finger 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Posh2; Ppp1r39

Gene ID: 307472 | Gene type: protein coding

About Sh3rf2

Summary

Predicted to enable protein Phosphatase 1 binding activity and ubiquitin protein Ligase activity. Involved in negative regulation of JNK cascade; negative regulation of apoptotic process; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Orthologous to human SH3RF2 (SH3 domain containing ring finger 2). [provided by Alliance of Genome Resources, Apr 2022]

Sh3rf2 Products(1)

mRNA Protein Name
NM_001034187.2 NP_001029359.1 E3 ubiquitin-protein ligase SH3RF2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22128169 RGD
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
22128169 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
22128169 RGD
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
22128169 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase SH3RF2

POSH-eliminating RING protein

RING finger protein 158

RING-type E3 ubiquitin transferase SH3RF2

SH3 domain-containing RING finger protein 2

protein phosphatase 1 regulatory subunit 39

putative E3 ubiquitin-protein ligase SH3RF2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12845 SH3RF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sh3rf2 NCBI NCBI:153769