Mdga1 - MAM domain containing glycosylphosphatidylinositol anchor 1 Gene

Rattus norvegicus

Gene ID: 309659 | Gene type: protein coding

About Mdga1

Summary

Involved in brain development; negative regulation of synapse assembly; and spinal cord association neuron differentiation. Is anchored component of plasma membrane. Orthologous to human MDGA1 (MAM domain containing glycosylphosphatidylinositol anchor 1). [provided by Alliance of Genome Resources, Apr 2022]

Mdga1 Products(1)

mRNA	Protein	Name
NM_001107618.1	NP_001101088.1	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in brain development	IEP IEP: Inferred from expression pattern	15019943	RGD
involved in negative regulation of synapse assembly	IDA IDA: Inferred from direct assay	23358245	RGD
involved in regulation of synapse maturation	IDA IDA: Inferred from direct assay	35532105	RGD
involved in regulation of synapse maturation	IMP IMP: Inferred from mutant phenotype	35532105	RGD
involved in spinal cord association neuron differentiation	IEP IEP: Inferred from expression pattern	15019943	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	35532105	RGD
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	35532105	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	35532105	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	35532105	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	15019943	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	35532105	RGD
is active in postsynaptic density membrane	IMP IMP: Inferred from mutant phenotype	35532105	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

MAM domain-containing glycosylphosphatidylinositol anchor protein 1

ig6M

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08258	MDGA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mdga1	NCBI	NCBI:266727

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