2. Gene
  3. MDGA1 - MAM domain containing glycosylphosphatidylinositol anchor 1 Gene

MDGA1 - MAM domain containing glycosylphosphatidylinositol anchor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GPIM; MAMDC3

Gene ID: 266727 | Gene type: protein coding

About MDGA1

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:37,630,679-37,697,883 (from NCBI)

This gene has 13 transcripts (splice variants), 201 orthologues and 4 paralogues. Broad expression in brain (RPKM 2.6), ovary (RPKM 2.3) and 21 other tissues.

Summary

This gene encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that is expressed predominantly in the developing nervous system. In addition to possessing several cell adhesion molecule-like domains, the mature protein has six Ig-like domains, a single fibronectin type III domain, a MAM domain and a C-terminal GPI-anchoring site. Studies in other mammals suggest this protein plays a role in cell adhesion, migration, and axon guidance and, in the developing brain, neuronal migration. In humans, this gene is associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2016]

MDGA1 Products(1)

mRNA Protein Name
NM_153487.4 NP_705691.1 MAM domain-containing glycosylphosphatidylinositol anchor protein 1 preproprotein

MDGA1 Protein Structure

I-set

I-set: Immunoglobulin I-set domain (48 - 115)

Ig_2

Ig_2: Immunoglobulin domain (147 - 220)

Ig_2

Ig_2: Immunoglobulin domain (243 - 326)

I-set

I-set: Immunoglobulin I-set domain (345 - 418)

I-set

I-set: Immunoglobulin I-set domain (450 - 517)

I-set

I-set: Immunoglobulin I-set domain (540 - 630)

MAM

MAM: MAM domain, meprin/A5/mu (753 - 917)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 955 a.a.
Protein Preferred Names Protein Names

MAM domain-containing glycosylphosphatidylinositol anchor protein 1

GPI and MAM protein

Related Diseases

Diseases Alias
Osgood-Schlatter'S Disease

Osgood-Schlatter Disease

Juvenile Osteochondrosis Of Tibial Tubercle

Osteochondrosis

Osteochondritis Of Tibial Tubercle

Osteochondrosis Of Proximal Tibia

Aseptic Necrosis Of The Tibial Tubercle

Osteochondrosis Of The Tibial Tubercle

Osteochondritis Juvenilis
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08258 MDGA1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MDGA1 MGD MGI:1922012
Macaca mulatta MDGA1 VGNC VGNC:74535
Felis catus MDGA1 VGNC VGNC:63425
Bos taurus MDGA1 VGNC VGNC:31331
Rattus norvegicus MDGA1 RGD RGD:1307031
Canis familiaris MDGA1 VGNC VGNC:43101