Arx - aristaless related homeobox Gene

Also Known as RGD1562672

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 317268

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in brain development and neuron development. Located in nucleus. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in X-linked lissencephaly 2; corpus callosum agenesis-abnormal genitalia syndrome; developmental and epileptic encephalopathy 1; and intellectual disability (multiple). Orthologous to human ARX (aristaless related homeobox). [provided by Alliance of Genome Resources, Apr 2022]

Arx Products (1)

mRNA Protein Name
NM_001100174.1 NP_001093644.1 homeobox protein ARX

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in neuron development IEP
IEP: Inferred from expression pattern
14992814 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein ARX

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-132987 Avibactam tomilopil Inhibitor 98.57% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990697 Anvatabart Inhibitor 98.15% Phase 3

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01051 ARX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15320 UBA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19646 Uba2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991204 Anti-PSMA Antibody Inhibitor 96.31% Unkown
HY-P991930 ARX305 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arx NCBI NCBI:170302