Hook3 - hook microtubule tethering protein 3 Gene

Also Known as 5830454D03Rik; E330005F07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 320191

Summary

Predicted to enable several functions, including cytoskeletal protein binding activity; dynein intermediate chain binding activity; and dynein light chain binding activity. Involved in negative regulation of neurogenesis. Acts upstream of or within several processes, including interkinetic nuclear migration; microtubule anchoring at centrosome; and neuronal stem cell population maintenance. Located in centriolar satellite; cytoplasm; and pericentriolar material. Is expressed in brain; future brain; and genitourinary system. Orthologous to human HOOK3 (hook microtubule tethering protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Hook3 Products (1)

mRNA Protein Name
NM_207659.3 NP_997542.1 protein Hook homolog 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20152126 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within interkinetic nuclear migration IMP
IMP: Inferred from mutant phenotype
20152126 MGI
involved in interkinetic nuclear migration IMP
IMP: Inferred from mutant phenotype
20152126 MGI
acts upstream of or within microtubule anchoring at centrosome IMP
IMP: Inferred from mutant phenotype
20152126 MGI
involved in negative regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
20152126 MGI
acts upstream of or within neuronal stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
20152126 MGI
acts upstream of or within protein localization to centrosome IMP
IMP: Inferred from mutant phenotype
20152126 MGI
involved in protein localization to centrosome IMP
IMP: Inferred from mutant phenotype
20152126 MGI
Cellular Component GO Annotation Evidence References Source
located in centriolar satellite IDA
IDA: Inferred from direct assay
20152126 MGI
located in centrosome IDA
IDA: Inferred from direct assay
20152126 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
20152126 MGI
located in pericentriolar material IDA
IDA: Inferred from direct assay
20152126 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Hook homolog 3

  • hook homolog 3

  • mHK3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06289 HOOK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hook3 NCBI NCBI:84376