HPGD - 15-hydroxyprostaglandin dehydrogenase Gene

Also Known as PGDH; PGDH1; PHOAR1; 15-PGDH; SDR36C1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3248

About HPGD

Cytogenetic location: 4q34.1 Genomic coordinates (GRCh38): 4:174,490,175-174,522,893 (from NCBI)

This gene has 14 transcripts (splice variants), 205 orthologues and is associated with 6 phenotypes. Biased expression in urinary bladder (RPKM 176.8), stomach (RPKM 67.9) and 11 other tissues.

Summary

This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

HPGD Products (8)

mRNA	Protein	Name
NM_001256305.2	NP_001243234.1	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 4
NM_001363574.2	NP_001350503.1	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 6
NM_001256301.1	NP_001243230.1	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 3
XR_938728.3
NM_000860.6	NP_000851.2	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1
NM_001256307.2	NP_001243236.1	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 3
NM_001256306.2	NP_001243235.1	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 5
NM_001145816.3	NP_001139288.1	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	2025296	GOA
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	IMP IMP: Inferred from mutant phenotype	8086429	GOA
enables NAD binding	IDA IDA: Inferred from direct assay	10198228	GOA
enables NAD+ binding	IDA IDA: Inferred from direct assay	16828555	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21072165	GOA
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA IDA: Inferred from direct assay	16757471	GOA
enables prostaglandin E receptor activity	IDA IDA: Inferred from direct assay	10198228	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in female pregnancy	IDA IDA: Inferred from direct assay	15531523	GOA
involved in negative regulation of cell cycle	IDA IDA: Inferred from direct assay	15574495	GOA
involved in parturition	IDA IDA: Inferred from direct assay	15531523	GOA
involved in prostaglandin metabolic process	IDA IDA: Inferred from direct assay	16828555	GOA
involved in regulation of prostaglandin catabolic process	IMP IMP: Inferred from mutant phenotype	8086429	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	15574495	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HPGD Protein Structure

adh_short

0
100
200
266 a.a.

Protein Preferred Names	Protein Names
15-hydroxyprostaglandin dehydrogenase [NAD(+)]	15-hydroxyprostaglandin dehydrogenase (NAD(+)) NAD+-dependent 15-hydroxyprostaglandin dehydrogenase eicosanoid/docosanoid dehydrogenase hydroxyprostaglandin dehydrogenase 15-(NAD) prostaglandin dehydrogenase 1 short chain dehydrogenase/reductase family 36C member 1

Recombinant HPGD Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70297	15-PGDH/HPGD Protein, Human (HEK293, His)	P15428-1 (M1-Q266)	≥ 95%, as determined by reducing SDS-PAGE.

HPGD Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81351	15 PGDH Antibody (YA1096)	IHC-P	Human
HY-P81351A	15 PGDH Antibody (YA1096)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Colorectal Adenoma	Colorectal Adenomas Adenoma Of Large Intestine
Colon Adenoma	Adenomatous Polyp Of Colon
Gastric Tubular Adenocarcinoma	Tubular Adenocarcinoma Of Stomach
Gastritis, Familial Giant Hypertrophic	Menetrier Disease Gastric Mucosal Hypertrophy Giant Hypertrophic Gastritis Hypertrophic Gastropathy Gastritis, Hypertrophic Familial Giant Hypertrophic Gastritis Giant Rugal Hypertrophy Of Stomach Hypertrophic Gastritis Gastroenteropathy, Protein Losing Giant Hypertrophic Gastropathy Giant Hypertrophy Of The Gastric Mucosa Hypoproteinemic Hypertrophic Gastropathy Menetrier'S Disease Giant Hypertrophic Hypersecretory Gastritis
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1	Cranioosteoarthropathy PHOAR1 Pachydermoperiostosis, Autosomal Recessive Touraine-Solente-Gole Syndrome Pho, Autosomal Recessive Pdp, Autosomal Recessive Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 Cranio Osteoarthropathy Cranio-Osteoarthropathy Currarino Disease Currarino Idiopathic Osteoarthropathy Reginato-Schiapachasse Syndrome Touraine-Solente-Golé Syndrome COA Pachydermoperiostosis Autosomal Recessive Pdp Autosomal Recessive Pho Autosomal Recessive Osteoarthropathy, Hypertrophic, Primary, Autosomal Recessive, Type 1 Osteoarthropathy, Primary Hypertrophic Reginato Schiapachasse Syndrome
Patent Ductus Arteriosus 1	Patent Ductus Arteriosus PDA1 Pda Ductus Arteriosus, Patent Patent Ductus Arteriosus, Susceptibility To Patent Ductus Botalli Patency Of The Ductus Arteriosus Patent Ductus Arteriosus Familial Ductus Arteriosus Patent Patent Ductus Arteriosus - Persisting Type
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Primary Hypertrophic Osteoarthropathy	Pachydermoperiostosis Syndrome Osteoarthropathy, Primary Hypertrophic Pachydermoperiostosis Of Nail Idiopathic Hypertrophic Osteoarthropathy Pho
Acroosteolysis	Acro-Osteolysis
Ureteral Obstruction
Colonic Benign Neoplasm	Colon Neoplasm Colonic Mass Colonic Tumor Neoplasm Of Colon Neoplasm Of The Colon Colonic Neoplasms Colon Cancer Colon Carcinoma Nos Colonic Cancer Metastatic Colon Cancer Nos
Lymphangioma	Lymphatic Malformation Lymphatic Malformations Benign Lymphangioma Congenital Lymphangioma Lymphangiomas
Periostitis
Digital Clubbing, Isolated Congenital	Isolated Congenital Digital Clubbing DIGC Clubbing Of Digits Acropachy, Hereditary Isolated Congenital Acropachy Isolated Congenital Nail Clubbing Hereditary Acropachy
Secondary Hypertrophic Osteoarthropathy	Osteoarthropathy, Secondary Hypertrophic Bamberger-Marie Disease Hpoa - Hypertrophic Pulmonary Osteoarthropathy Hypertrophic Pulmonary Osteoarthropathy Marie Bamberger Disease
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Congenital Anomaly Of Heart Heart Defect Heart Malformation Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Acromegaloid Changes, Cutis Verticis Gyrata, And Corneal Leukoma	Pachydermoperiostosis Rosenthal-Kloepfer Syndrome Pdp Acromegaloid Changes, Cutis Verticis Gyrata And Corneal Leukoma Idiopathic Hypertrophic Osteoarthropathy Primary Hypertrophic Osteoarthropathy Touraine Solente Gole Syndrome Touraine-Solente-Gole Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-116449	2-Benzoylthiophene		99.90%	Phase 1

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108259	HQL-79	Inhibitor	99.89%	Unkown
HY-10439	HPGDS inhibitor 1	Inhibitor	99.42%	Unkown
HY-12791	hPGDS-IN-1	Inhibitor	99.92%	Unkown
HY-139972	PROTAC(H-PGDS)-7		99.42%	Unkown
HY-110167	TFC 007	Inhibitor	98.01%	Unkown
HY-126134	HPGDS inhibitor 2	Inhibitor	99.70%	Unkown
HY-146662	HPGDS inhibitor 3	Inhibitor	/	Unkown
HY-157577	PROTAC(H-PGDS)-8	Degrader	/	Unkown
HY-RS06338	HPGD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06339	Hpgd Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06340	Hpgd Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06341	HPGDS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-120581	ML388	Inhibitor	/	Unkown
HY-139171	F092	Inhibitor	99.79%	Unkown
HY-RS17229	Hpgds Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23682	Hpgds Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HPGD	VGNC	VGNC:56973
Macaca mulatta	HPGD	VGNC	VGNC:73512
Felis catus	HPGD	VGNC	VGNC:67638
Canis familiaris	HPGD	VGNC	VGNC:49605
Mus musculus	HPGD	MGD	MGI:108085
Rattus norvegicus	HPGD	RGD	RGD:620087
Others	HPGD	NCBI