Successful, we will reply to you quickly.OK
Please select the quantity.OK
Your message is being sent, please wait.Close
Send mail failed, please send again!Close
Products are for research use only. Not for human use. We do not sell to patients.
hPGDS-IN-1 Chemical Structure
|Product name: hPGDS-IN-1|
|Cat. No.: HY-12791|
hPGDS-IN-1 is a hPGDS inhibitor ,with IC50 of 12 nM in the Fluorescence Polarization Assay or the EIA assay.
IC50 value: 12 nM
The detailed information please refer to WO2011044307A1 and WO2010080563A2
|M.Wt||416.43||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO: ≥ 35 mg/mL
|1 mg||5 mg||10 mg|
|1 mM||2.4014 mL||12.0068 mL||24.0136 mL|
|5 mM||0.4803 mL||2.4014 mL||4.8027 mL|
|10 mM||0.2401 mL||1.2007 mL||2.4014 mL|
. Vandeusen, Christopher L, et al. Phenyloxadiazole derivatives as PGD inhibitors and their preparation, pharmaceutical compositions and use in the treatment of allergic and inflammatory disorders. From PCT Int. Appl. (2011), WO 2011044307 A1 20110414.
. Weiberth Franz J, et al. Demonstration on Pilot-Plant Scale of the Utility of 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) as a Catalyst in the Efficient Amidation of an Unactivated Methyl Ester. From Organic Process Research & Development (2012), 16(12), 1967-1969.
5-Aminosalicylic acid is an anti-inflammatory compound.
Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity.
HPGDS inhibitor 1 is a novel and selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value of 0.7 nM.
MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively.
Pranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology.
Suprofen is a non-steroidal anti-inflammatory drug (NSAID).
Zomepirac sodium salt is a pyrrole-acetic acid structurally related to tolmetin sodium; a prostaglandin synthetase inhibitor.