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製品番号: HY-12791

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hPGDS-IN-1

Name: hPGDS-IN-1
Brand: MedChemExpress
SKU: HY-12791
Price: 200.00 USD
Availability: InStock
Rating: 5 (3 reviews)

3 Cited Publications

カスタマーレビュー

Based on 3 publication(s) in Google Scholar

hPGDS-IN-1 (Compound 2) is an hPGDS inhibitor with an IC₅₀ of 12 nM (as measured by fluorescence polarization assay or EIA). hPGDS-IN-1 can be used in the research of allergic rhinitis and spinal cord neurons.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度 : 99.92%
CAS 番号: 1234708-04-3
分子式: C₂₂H₂₀N₆O₃
分子量:416.43

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

hPGDS-IN-1 構造式

CAS 番号: 1234708-04-3

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

hPGDS-IN-1 (Compound 2^[3]) is an hPGDS inhibitor with an IC₅₀ of 12 nM (as measured by fluorescence polarization assay or EIA). hPGDS-IN-1 can be used in the research of allergic rhinitis and spinal cord neurons^[1]^[2]^[3].

IC₅₀ & Target

IC₅₀: 12 nM (hPGDS)^[1]^[2]^[3]

体外実験

hPGDS-IN-1 causes a significant reduction in the numbers of 5-HT-ir spinal cord neurons of 4 dpf zebrafish^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1234708-04-3
性状 Solid
分子量 416.43
分子式 C₂₂H₂₀N₆O₃
Color White to off-white
SMILES

OC(C)(C)C1=NC(C2=CC(CNC(C(C=N3)=CN=C3C4=CC=CC=N4)=O)=CC=C2)=NO1
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (3)

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Acta Pharm Sin B

DeepICER: A deep learning framework for predicting compound-induced gene expression profiles. [Abstract]

2026 May;16(5):2947-2963. PMID: 42180546
Acta Pharm Sin B

2026 Feb.
bioRxiv

2023 Oct 8.

溶剤 & 溶解度

体外:

DMSO : 16.67 mg/mL (40.03 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4014 mL

12.0068 mL

24.0136 mL

5 mM

0.4803 mL

2.4014 mL

4.8027 mL

10 mM

0.2401 mL

1.2007 mL

2.4014 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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希釈計算機

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
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Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Vandeusen, Christopher L, et al. Phenyloxadiazole derivatives as PGD inhibitors and their preparation, pharmaceutical compositions and use in the treatment of allergic and inflammatory disorders. From PCT Int. Appl. (2011), WO 2011044307 A1 20110414.

[2]. Hahn Chang S. Method for treating macular degeneration using syk multikinase inhibitor, an hPGDS inhibitor and a DP antagonist. From PCT Int. Appl. (2010), WO 2010080563 A2 20100715.

[3]. Weiberth Franz J, et al. Demonstration on Pilot-Plant Scale of the Utility of 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) as a Catalyst in the Efficient Amidation of an Unactivated Methyl Ester. From Organic Process Research & Development (2012), 16(12), 1967-1969.

[4]. González-Llera L, et al. An in vivo drug screen in zebrafish reveals that cyclooxygenase 2-derived prostaglandin D2 promotes spinal cord neurogenesis. Cell Prolif. 2024 May;57(5):e13594. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4014 mL	12.0068 mL	24.0136 mL	60.0341 mL
	5 mM	0.4803 mL	2.4014 mL	4.8027 mL	12.0068 mL
	10 mM	0.2401 mL	1.2007 mL	2.4014 mL	6.0034 mL
	15 mM	0.1601 mL	0.8005 mL	1.6009 mL	4.0023 mL
	20 mM	0.1201 mL	0.6003 mL	1.2007 mL	3.0017 mL
	25 mM	0.0961 mL	0.4803 mL	0.9605 mL	2.4014 mL
	30 mM	0.0800 mL	0.4002 mL	0.8005 mL	2.0011 mL
	40 mM	0.0600 mL	0.3002 mL	0.6003 mL	1.5009 mL

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Keywords

hPGDS-IN-1

3 Cited Publications

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hPGDS-IN-1

MedChemExpress（MCE）の使用を引用している文献 hPGDS-IN-1

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