15 PGDH Antibody (YA1096)(PBS only)

Cat. No.: HY-P81351A: Data Sheet User Guide for Antibodies
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15 PGDH Antibody (YA1096) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 15 PGDH.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation
References

Description

15 PGDH Antibody (YA1096) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 15 PGDH.

Host

Rabbit

Molecular Weight

Predicted band size: 29 kDa;

Observed band size: 29 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P15428

Gene ID

3248 [NCBI]

Immunogen

Recombinant protein of human 15-PGDH

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-1:200

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (PubMed:10837478, PubMed:16757471, PubMed:16828555, PubMed:21916491, PubMed:25586183, PubMed:8086429). Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression (PubMed:15574495, PubMed:25586183). Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation (PubMed:16757471, PubMed:22844113)

Subcellular Localization：Cytoplasm

Expression：
Tissue_specificity:Detected in colon epithelium (at protein level)

Induction:Down-regulated by cortisol, dexamethasone and betamethasone. Down-regulated in colon cancer. Up-regulated by TGFB1

Isoforms & Post-Translational Modification：P15428 has 5 isomers: P15428-1: 28977 Da (predicted); P15428-2: 19284 Da (predicted); P15428-3: 15696 Da (predicted); P15428-4: 15534 Da (predicted); P15428-5: 21526 Da (predicted).

Subunit：Homodimer

Research Field

Immunology

Synonyms

15-PGDH; Hpgd; PGDH; PGDH1; PHOAR1; SDR36C1

Documentation

User Guide for Antibodies (1077 KB)

References

[1]. /biology-dictionary/hep-3b2-cell.html [Content Brief]