HTN1 - histatin 1 Gene

Also Known as HIS1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3346

About HTN1

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,050,438-70,058,848 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 15 orthologues and 2 paralogues. Restricted expression toward salivary gland (RPKM 17545.5).

Summary

This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit Antibacterial, Antifungal activities and function in wound healing. [provided by RefSeq, Aug 2014]

HTN1 Products (2)

mRNA Protein Name
NM_001368990.1 NP_001355919.1 histatin-1 isoform 2 precursor
NM_002159.4 NP_002150.1 histatin-1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16203048 GOA
Biological Process GO Annotation Evidence References Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
3286634 GOA
involved in killing of cells of another organism IDA
IDA: Inferred from direct assay
3286634 GOA
involved in positive regulation of cell-cell adhesion IDA
IDA: Inferred from direct assay
25903106 GOA
involved in positive regulation of metabolic process IDA
IDA: Inferred from direct assay
28542418 GOA
involved in positive regulation of metabolic process IMP
IMP: Inferred from mutant phenotype
32225006 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IDA
IDA: Inferred from direct assay
25903106 GOA
involved in positive regulation of vascular wound healing IDA
IDA: Inferred from direct assay
28751526 GOA
involved in positive regulation of wound healing IDA
IDA: Inferred from direct assay
18650243 GOA
involved in positive regulation of wound healing, spreading of epidermal cells IDA
IDA: Inferred from direct assay
28751526 GOA
Cellular Component GO Annotation Evidence References Source
is active in endoplasmic reticulum IDA
IDA: Inferred from direct assay
34233061 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
32225006 GOA
is active in endoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
32225006 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
3286634 GOA
is active in mitochondrion IDA
IDA: Inferred from direct assay
35970844 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
32225006 GOA
is active in mitochondrion IMP
IMP: Inferred from mutant phenotype
32225006 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histatin-1

  • PPB

HTN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HTN1 P15515 MUC7 Homo sapiens Q8TAX7
Y2H
16203048
Intra
HTN1 P15515 MUC7 Homo sapiens Q8TAX7
Far-WB
16203048
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypertension And Brachydactyly Syndrome

  • Brachydactyly With Hypertension

  • Bilginturan Syndrome

  • HTNB

  • Brachydactyly-Arterial Hypertension Syndrome

  • Brachydactyly, Type E, With Short Stature And Hypertension

  • Bilginturan Brachydactyly

  • Brachydactyly Type E With Short Stature And Hypertension

  • Type E Brachydactyly With Short Stature And Hypertension

  • Brachydactyly Type E, With Short Stature And Hypertension

  • Hypertension With Brachydactyly
Candida Glabrata

  • Torulopsis Glabrata
Dental Caries

  • Dental Caries Extending Into Pulp

  • Dental Caries Of Smooth Surface

  • Dental Caries Pit And Fissure

  • Smooth Surface Dental Caries

  • Dental Decay

  • Carious Teeth

  • Dental Cavity

  • Saprodontia

  • Teeth Decayed

  • Tooth Caries

  • Tooth Decay
Acute Apical Periodontitis

  • Acute Apical Periodontitis Of Pulpal Origin

  • Acute Apical Periodontitis Nos

  • Aap - [Acute Apical Periodontitis]
Renal Artery Atheroma

  • Atherosclerosis Of Renal Artery

  • Renal Atherosclerosis

  • Atherosclerotic Renal Disease

  • Ras - [Renal Artery Stenosis]

  • Renal Arterial Arteriosclerosis

  • Renal Arterial Arteriosclerotic Disease

  • Renal Arterial Stricture

  • Renal Artery Stricture

  • Renal Artery Stenosis Of Unknown Cause

  • Renal Artery Stenosis Due To Atherosclerosis

  • Renal Artery Stenosis

  • Renal Artery Arteriosclerotic Disease

  • Renal Artery Arteriosclerosis
Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly

  • Asphyxiating Thoracic Dystrophy 2

  • SRTD2

  • Atd2

  • Jatd

  • Jeune Asphyxiating Thoracic Dystrophy

  • Jeune Syndrome 2
Renal Artery Disease

  • Renal Vascular Disease

  • Vascular Disorder Of Kidney

  • Renal Vascular Disorder
Sialolithiasis

  • Sialolith

  • Stone Of Salivary Gland Or Duct

  • Salivary Gland Calculi

  • Salivary Gland Stone

  • Calculus Of Salivary Gland Or Duct

  • Calculus Of Salivary Gland

  • Salivary Calculus

  • Salivary Gland Calculus

  • Salivary Stone

  • Salivary Duct Calculi

  • Sialodocholithiasis
Wrinkly Skin Syndrome

  • WSS

  • Wrinkled Skin Syndrome
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06456 HTN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown