APOA4 - apolipoprotein A4 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 337

About APOA4

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:116,820,700-116,823,304 (from NCBI)

This gene has 1 transcript (splice variant), 116 orthologues and 3 paralogues. Restricted expression toward small intestine (RPKM 1486.2).

Summary

Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol Acyltransferase in vitro. [provided by RefSeq, Jul 2008]

APOA4 Products (1)

mRNA	Protein	Name
NM_000482.4	NP_000473.2	apolipoprotein A-IV precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables antioxidant activity	IDA IDA: Inferred from direct assay	16945374	GOA
enables cholesterol transfer activity	IDA IDA: Inferred from direct assay	1935934	GOA
enables copper ion binding	IDA IDA: Inferred from direct assay	16945374	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22579246	GOA
enables lipid binding	IMP IMP: Inferred from mutant phenotype	16159879	GOA
enables phosphatidylcholine binding	IDA IDA: Inferred from direct assay	1935934	GOA
enables phosphatidylcholine-sterol O-acyltransferase activator activity	IDA IDA: Inferred from direct assay	1935934	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24311788	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	1935934	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cholesterol efflux	IDA IDA: Inferred from direct assay	1935934	GOA
involved in cholesterol homeostasis	IDA IDA: Inferred from direct assay	1935934	GOA
involved in cholesterol metabolic process	IDA IDA: Inferred from direct assay	1935934	GOA
involved in high-density lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	1935934	GOA
involved in hydrogen peroxide catabolic process	IDA IDA: Inferred from direct assay	16945374	GOA
involved in innate immune response in mucosa	IDA IDA: Inferred from direct assay	15254593	GOA
involved in leukocyte cell-cell adhesion	IDA IDA: Inferred from direct assay	15254593	GOA
involved in lipid catabolic process	IDA IDA: Inferred from direct assay	3095477	GOA
involved in lipid homeostasis	IDA IDA: Inferred from direct assay	3095477	GOA
involved in lipid transport	IDA IDA: Inferred from direct assay	1935934	GOA
involved in negative regulation of plasma lipoprotein oxidation	IDA IDA: Inferred from direct assay	16945374	GOA
involved in phosphatidylcholine metabolic process	IDA IDA: Inferred from direct assay	1935934	GOA
involved in phospholipid efflux	IDA IDA: Inferred from direct assay	11162594	GOA
involved in positive regulation of CoA-transferase activity	IDA IDA: Inferred from direct assay	1935934	GOA
involved in positive regulation of fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	2307668	GOA
involved in positive regulation of lipoprotein lipase activity	IDA IDA: Inferred from direct assay	2307668	GOA
involved in positive regulation of triglyceride catabolic process	IDA IDA: Inferred from direct assay	2307668	GOA
involved in protein-lipid complex assembly	IMP IMP: Inferred from mutant phenotype	16159879	GOA
involved in regulation of cholesterol transport	IDA IDA: Inferred from direct assay	11940599	GOA
involved in removal of superoxide radicals	IDA IDA: Inferred from direct assay	16945374	GOA
involved in response to lipid hydroperoxide	IDA IDA: Inferred from direct assay	16945374	GOA
involved in reverse cholesterol transport	IDA IDA: Inferred from direct assay	3095477	GOA
involved in very-low-density lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	2307668	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with cell surface	IDA IDA: Inferred from direct assay	1935934	GOA
part of chylomicron	IDA IDA: Inferred from direct assay	3095477	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	1935934	GOA
part of high-density lipoprotein particle	IDA IDA: Inferred from direct assay	3095477	GOA
part of very-low-density lipoprotein particle	IDA IDA: Inferred from direct assay	3095477	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOA4 Protein Structure

Apolipoprotein

0
100
200
300
396 a.a.

Protein Preferred Names	Protein Names
apolipoprotein A-IV	apo-AIV

APOA4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	APOA4	P06727	MAGEA6	Homo sapiens	P43360	Validated Y2H	32296183
Intra	APOA4	P06727	MAGEA6	Homo sapiens	P43360	Y2H Array	32296183
Intra	APOA4	P06727	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	32296183
Intra	APOA4	P06727	AGTRAP	Homo sapiens	Q6RW13-2	Validated Y2H	32296183
Intra	APOA4	P06727	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Prey Pooling	32296183
Intra	APOA4	P06727	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	32296183
Intra	APOA4	P06727	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	APOA4	P06727	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	32296183
Intra	APOA4	P06727	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Prey Pooling	32296183
Intra	APOA4	P06727	APOA4	Homo sapiens	P06727	Crosslink	22579246
Intra	APOA4	P06727	CMTM4	Homo sapiens	Q8IZR5-2	Validated Y2H	32296183
Intra	APOA4	P06727	APOA4	Homo sapiens	P06727	GMS	22579246
Intra	APOA4	P06727	CMTM4	Homo sapiens	Q8IZR5-2	Y2H Array	32296183
Intra	APOA4	P06727	APOA4	Homo sapiens	P06727	Comig Non-Denat Gel	22579246
Intra	APOA4	P06727	CMTM4	Homo sapiens	Q8IZR5-2	Y2H Prey Pooling	32296183
Intra	APOA4	P06727	APOA4	Homo sapiens	P06727	Solution Sedimentation	22579246
Intra	APOA4	P06727	APOA4	Homo sapiens	P06727	X-Ray Diffraction	22579246

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant APOA4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7528	ApoA-IV Protein, Human (HEK293, His)	P06727 (E21-S396)	≥ 95%, as determined by reducing SDS-PAGE.

APOA4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82847	APOA4 Antibody (YA2592)	WB, IP	Human
HY-P83975	APOA4 Antibody (YA3672)	WB, ELISA	Human
HY-P83975A	APOA4 Antibody (YA3672)(PBS only)	WB, ELISA	Human
HY-P85039	ApoA-IV Antibody (YA4731)	WB, ELISA	Human

Related Diseases

Diseases	Alias
Familial Hyperlipidemia	Familial Hyperlipoproteinemia Hyperlipidaemia Hyperlipoproteinemias Hyperlipidemia Hyperlipemia Hyperlipidemias
Familial Hypercholesterolemia	Hyperlipoproteinemia Type Iia Familial Hyperbetalipoproteinaemia Familial Hypercholesteremia Fredrickson Type Iia Hyperlipoproteinemia Fredrickson Type Iia Lipidaemia Hyperbetalipoproteinemia Type Ii Hyperlipidemia Familial Hypercholesterolæmia Familial Hypercholesterolaemia Fh Hypercholesterolemia Familial Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial
Carotenemia	Hypercarotinemia
Amyloidosis, Familial Visceral	Ostertag Type Amyloidosis German Type Amyloidosis Familial Renal Amyloidosis Amyloidosis Viii Amyloidosis, 3 Or More Types Familial Visceral Amyloidosis Familial Amyloid Nephropathy Hereditary Amyloid Nephropathy Amyloidosis, Familial Renal Amyloidosis, Systemic Nonneuropathic Amyloidosis Familial Visceral Amyloidosis 8 Amyloidosis, Ostertag Type Hereditary Amyloidosis With Primary Renal Involvement Hereditary Renal Amyloidosis Renal Amyloidosis Amyloidosis, Renal Systemic Nonneuropathic Amyloidosis Amyloidosis Familial Renal Amyloidosis Systemic Nonneuropathic Hereditary Amyloidosis With Primary Renal Involement AMYL8 Systemic Non-Neuropathic Amyloidosis Amyloid Nephropathy
Apolipoprotein A-Iv Associated Amyloidosis	Aapoaiv Amyloidosis Renal Aapoaiv Amyloidosis Apolipoprotein A-Iv Amyloidosis
Thrombophilia Due To Hrg Deficiency	Hereditary Thrombophilia Due To Congenital Histidine-Rich Glycoprotein Deficiency Hereditary Thrombophilia Due To Congenital Hrg Deficiency Thph11
Hyperlipidemia, Familial Combined, 3	Familial Combined Hyperlipidemia Combined Hyperlipidemia, Familial Mixed Hyperlipidaemia FCHL3 Hyperlipidemia, Familial Combined Familial Multiple Lipoprotein-Type Hyperlipidemia Hyperbetalipoproteinemia With Prebetalipoproteinemia Type Iib Hyperlipoproteinemia Hyperlipidemia Familial Combined Hyperlipoproteinemia Type Iib Mixed Hyperlipemia Hyperlipidaemia, Group C Familial Hypercholesterolaemia With Hyperlipaemia Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia Hyperbetalipoproteinaemia With Prebetalipoproteinaemia Hypercholesterolaemia With Endogenous Hyperglyceridaemia Prebetalipoproteinemia Hyperbetalipoproteinaemia Remnant Hyperlipoproteinemia
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Chylomicron Retention Disease	CMRD Anderson Disease Lipid Transport Defect Of Intestine Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells Andd Anderson Syndrome Crd Andersons Disease Malabsorption Syndrome
Hypoalphalipoproteinemia, Primary, 2	Apolipoprotein A-I Deficiency Hypoalphalipoproteinemia, Primary, 2, Autosomal Recessive Primary Hypoalphalipoproteinemia 2 High Density Lipoprotein Deficiency Apoa-I Deficiency Familial Apoa-I Deficiency Familial Hypoalphalipoproteinemia FHA2 Apolipoprotein A-I
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Diabetes Mellitus	Diabetes
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Glycogen Storage Disease	Glycogenosis Glycogenoses Gsd Storage Disease, Glycogen Gsd - [Glycogen Storage Disease] Glycogen Thesaurismosis Diffuse Glycogenosis Generalised Glycogen Storage Disease Generalised Glycogenosis Generalised Glycogen Storage Disease Of Infants Glycogen Synthase Deficiency
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS19408	Apoa4 Mouse Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	APOA4	MGD	MGI:88051
Felis catus	APOA4	VGNC	VGNC:81902
Rattus norvegicus	APOA4	RGD	RGD:2132
Macaca mulatta	APOA4	VGNC	VGNC:82104
Bos taurus	APOA4	VGNC	VGNC:26024
Canis familiaris	APOA4	VGNC	VGNC:53263
Others	APOA4	NCBI