PRSS53 - serine protease 53 Gene

Also Known as POL3S; UNQ308

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 339105

About PRSS53

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:31,083,437-31,088,943 (from NCBI)

This gene has 3 transcripts (splice variants), 143 orthologues and 1 paralogue. Ubiquitous expression in skin (RPKM 1.8), spleen (RPKM 1.6) and 25 other tissues.

Summary

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

PRSS53 Products (1)

mRNA	Protein	Name
NM_001039503.3	NP_001034592.1	serine protease 53 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRSS53 Protein Structure

Trypsin

0
100
200
300
400
500
553 a.a.

Protein Preferred Names	Protein Names
serine protease 53	EDTP308

PRSS53 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRSS53	Q2L4Q9	UBAP2	Homo sapiens	Q5T6F2	Y2H Prey Pooling	32296183
Intra	PRSS53	Q2L4Q9	UBAP2	Homo sapiens	Q5T6F2	Validated Y2H	32296183
Intra	PRSS53	Q2L4Q9	UBAP2	Homo sapiens	Q5T6F2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Coumarin Resistance	Warfarin Resistance Warfarin Sensitivity Coumadin Sensitivity Warfarin Response Poor Metabolism Of Coumarin Coumarin, Poor Metabolism Of CMRES
Episodic Kinesigenic Dyskinesia 1	Paroxysmal Kinesigenic Choreoathetosis Paroxysmal Kinesigenic Dyskinesia Dystonia 10 Familial Paroxysmal Kinesigenic Dyskinesia Episodic Kinesigenic Dyskinesia EKD1 Pkc Pkd Dyt10 Familial Pkd Paroxysmal Kinesigenic Choreathetosis Familial Paroxysmal Dystonia Dystonia, Familial Paroxysmal Dyt-Prrt2 Dystonia, Type 10

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11256	PRSS53 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PRSS53	VGNC	VGNC:33423
Mus musculus	PRSS53	MGD	MGI:2652890
Rattus norvegicus	PRSS53	RGD	RGD:1566127
Felis catus	PRSS53	VGNC	VGNC:64402
Canis familiaris	PRSS53	VGNC	VGNC:45070