SP110 - SP110 nuclear body protein Gene

Homo sapiens

Also known as IPR1; VODI; IFI41; IFI75

Gene ID: 3431 | Gene type: protein coding

About SP110

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:230,165,186-230,225,636 (from NCBI)

This gene has 21 transcripts (splice variants), 120 orthologues, 20 paralogues and is associated with 3 phenotypes. Broad expression in spleen (RPKM 11.2), lymph node (RPKM 10.7) and 24 other tissues.

Summary

The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008]

SP110 Products(10)

mRNA	Protein	Name
NM_001185015.2	NP_001171944.1	sp110 nuclear body protein isoform d
NM_001378442.1	NP_001365371.1	sp110 nuclear body protein isoform 3
NM_001378443.1	NP_001365372.1	sp110 nuclear body protein isoform f
NM_001378444.1	NP_001365373.1	sp110 nuclear body protein isoform g
NM_001378445.1	NP_001365374.1	sp110 nuclear body protein isoform h
NM_001378446.1	NP_001365375.1	sp110 nuclear body protein isoform i
NM_001378447.1	NP_001365376.1	sp110 nuclear body protein isoform j
NM_004509.5	NP_004500.4	sp110 nuclear body protein isoform a
NM_004510.4	NP_004501.4	sp110 nuclear body protein isoform b
NM_080424.4	NP_536349.3	sp110 nuclear body protein isoform c

SP110 Protein Structure

HSR

SAND

0
200
400
600
689 a.a.

Protein Preferred Names

Protein Names

sp110 nuclear body protein

interferon-induced protein 41, 30kD

Related Diseases

Diseases

Alias

Hepatic Venoocclusive Disease With Immunodeficiency

VODI	Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Hepatic Veno-Occlusive Disease With Immunodeficiency	Familial Veno-Occlusive Disease With Immunodeficiency
Veno-Occlusive Disease And Immunodeficiency Syndrome	Vodi Syndrome
Vodi - [Veno-Occlusive Disease Immunodeficiency] Syndrome

Hepatic Veno-Occlusive Disease

Veno-Occlusive Disease	Sinusoidal Obstruction Syndrome
Hepatic Venoocclusive Disease	Venoocclusive Disease
Hepatic Vein Thrombosis	Budd-Chiari Syndrome
Hepatic Vein Occlusion	Veno-Occlusive Disease Of The Liver

Lipid Pneumonia

Exogenous Lipoid Pneumonia	Lipoid Pneumonitis
Pneumonia, Lipid	Pneumonia Lipid
Lipoid Pneumonia

Combined T And B Cell Immunodeficiency

Aspiration Pneumonitis

Chemical Pneumonitis	Mendelson'S Syndrome
Aspiration Pneumonia	Pneumonitis Due To Fumes And/Or Vapors
Toxic Pneumonitis	Mendelson'S Syndrome Resulting From A Procedure
Mendelson Syndrome Resulting From A Procedure	Pulmonary Acid Aspiration Syndrome
Pneumonitis Due To Inhalation Of Gastric Secretions	Mendelson Syndrome Due To Anaesthesia During Labour And Delivery
Inhalation Of Stomach Contents Or Secretions, Nos Due To Anaesthesia During Labour And Delivery

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13602	SP110 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SP110	VGNC	VGNC:99405
Rattus norvegicus	SP110	RGD	RGD:1310173
Mus musculus	SP110	MGD	MGI:1923364
Bos taurus	SP110	VGNC	VGNC:106948
Canis familiaris	SP110	VGNC	VGNC:46685

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