SP110 - SP110 nuclear body protein Gene

Also Known as IPR1; VODI; IFI41; IFI75

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3431

About SP110

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:230,165,186-230,225,636 (from NCBI)

This gene has 21 transcripts (splice variants), 120 orthologues, 20 paralogues and is associated with 3 phenotypes. Broad expression in spleen (RPKM 11.2), lymph node (RPKM 10.7) and 24 other tissues.

Summary

The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008]

SP110 Products (10)

mRNA	Protein	Name
NM_001185015.2	NP_001171944.1	sp110 nuclear body protein isoform d
NM_001378442.1	NP_001365371.1	sp110 nuclear body protein isoform 3
NM_001378443.1	NP_001365372.1	sp110 nuclear body protein isoform f
NM_001378444.1	NP_001365373.1	sp110 nuclear body protein isoform g
NM_001378445.1	NP_001365374.1	sp110 nuclear body protein isoform h
NM_001378446.1	NP_001365375.1	sp110 nuclear body protein isoform i
NM_001378447.1	NP_001365376.1	sp110 nuclear body protein isoform j
NM_004509.5	NP_004500.4	sp110 nuclear body protein isoform a
NM_004510.4	NP_004501.4	sp110 nuclear body protein isoform b
NM_080424.4	NP_536349.3	sp110 nuclear body protein isoform c

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	25593309	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SP110 Protein Structure

HSR

SAND

0
200
400
600
689 a.a.

Protein Preferred Names	Protein Names
sp110 nuclear body protein	interferon-induced protein 41, 30kD

SP110 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87083	SP110 Antibody (YA6776)	WB, IHC-P, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hepatic Venoocclusive Disease With Immunodeficiency	VODI Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome Hepatic Veno-Occlusive Disease With Immunodeficiency Familial Veno-Occlusive Disease With Immunodeficiency Veno-Occlusive Disease And Immunodeficiency Syndrome Vodi Syndrome Vodi - [Veno-Occlusive Disease Immunodeficiency] Syndrome
Hepatic Veno-Occlusive Disease	Veno-Occlusive Disease Sinusoidal Obstruction Syndrome Hepatic Venoocclusive Disease Venoocclusive Disease Hepatic Vein Thrombosis Budd-Chiari Syndrome Hepatic Vein Occlusion Veno-Occlusive Disease Of The Liver
Lipid Pneumonia	Exogenous Lipoid Pneumonia Lipoid Pneumonitis Pneumonia, Lipid Pneumonia Lipid Lipoid Pneumonia
Combined T And B Cell Immunodeficiency
Aspiration Pneumonitis	Chemical Pneumonitis Mendelson'S Syndrome Aspiration Pneumonia Pneumonitis Due To Fumes And/Or Vapors Toxic Pneumonitis Mendelson'S Syndrome Resulting From A Procedure Mendelson Syndrome Resulting From A Procedure Pulmonary Acid Aspiration Syndrome Pneumonitis Due To Inhalation Of Gastric Secretions Mendelson Syndrome Due To Anaesthesia During Labour And Delivery Inhalation Of Stomach Contents Or Secretions, Nos Due To Anaesthesia During Labour And Delivery

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10769	PMP22 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13602	SP110 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22816	Sp110 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29331	Sp110 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SP110	VGNC	VGNC:99405
Rattus norvegicus	SP110	RGD	RGD:1310173
Mus musculus	SP110	MGD	MGI:1923364
Bos taurus	SP110	VGNC	VGNC:106948
Canis familiaris	SP110	VGNC	VGNC:46685