SERINC2 - serine incorporator 2 Gene

Also Known as TDE2; TDE2L; FKSG84; PRO0899

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 347735

About SERINC2

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:31,409,777-31,434,678 (from NCBI)

This gene has 6 transcripts (splice variants), 276 orthologues and 4 paralogues. Broad expression in urinary bladder (RPKM 35.4), colon (RPKM 35.3) and 17 other tissues.

Summary

Predicted to be involved in several processes, including phosphatidylserine metabolic process; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity; and positive regulation of serine C-palmitoyltransferase activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

SERINC2 Products (5)

mRNA	Protein	Name
NM_001199037.2	NP_001185966.1	serine incorporator 2 isoform 3
NM_001199038.2	NP_001185967.1	serine incorporator 2 isoform 4
NM_001199039.2	NP_001185968.1	serine incorporator 2 isoform 5
NM_018565.4	NP_061035.2	serine incorporator 2 isoform 2
NM_178865.5	NP_849196.2	serine incorporator 2 isoform 1 precursor

SERINC2 Protein Structure

Serinc

0
100
200
300
400
455 a.a.

Protein Preferred Names	Protein Names
serine incorporator 2	tumor differentially expressed protein 2

Related Diseases

Diseases	Alias
Ayme-Gripp Syndrome	AYGRP Cataracts, Congenital, With Sensorineural Deafness, Down Syndrome-Like Facial Appearance, Short Stature, And Mental Retardation Aymé-Gripp Syndrome Fine-Lubinsky Syndrome Brachycephaly-Deafness-Cataract-Intellectual Disability Syndrome Brachycephaly-Hearing Loss-Cataract-Intellectual Disability Syndrome
Duane Retraction Syndrome	Stilling-Turk-Duane Syndrome Duane'S Syndrome Duane Syndrome Isolated Duane Retraction Syndrome Co-Contractive Retraction Syndrome Duane Anomaly, Isolated Ocular Retraction Syndrome Drs Durs
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12691	SERINC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22027	Serinc2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SERINC2	MGD	MGI:1919132
Bos taurus	SERINC2	VGNC	VGNC:106920
Macaca mulatta	SERINC2	VGNC	VGNC:77294
Canis familiaris	SERINC2	VGNC	VGNC:46020
Rattus norvegicus	SERINC2	RGD	RGD:1311396
Felis catus	SERINC2	VGNC	VGNC:65018
Others	SERINC2	NCBI