SERINC2 - serine incorporator 2 Gene

Homo sapiens

Also known as TDE2; TDE2L; FKSG84; PRO0899

Gene ID: 347735 | Gene type: protein coding

About SERINC2

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:31,409,777-31,434,678 (from NCBI)

This gene has 6 transcripts (splice variants), 276 orthologues and 4 paralogues. Broad expression in urinary bladder (RPKM 35.4), colon (RPKM 35.3) and 17 other tissues.

Summary

Predicted to be involved in several processes, including phosphatidylserine metabolic process; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity; and positive regulation of serine C-palmitoyltransferase activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

SERINC2 Products(5)

mRNA	Protein	Name
NM_001199037.2	NP_001185966.1	serine incorporator 2 isoform 3
NM_001199038.2	NP_001185967.1	serine incorporator 2 isoform 4
NM_001199039.2	NP_001185968.1	serine incorporator 2 isoform 5
NM_018565.4	NP_061035.2	serine incorporator 2 isoform 2
NM_178865.5	NP_849196.2	serine incorporator 2 isoform 1 precursor

SERINC2 Protein Structure

Serinc

0
100
200
300
400
455 a.a.

Protein Preferred Names

Protein Names

serine incorporator 2

tumor differentially expressed protein 2

Related Diseases

Diseases

Alias

Ayme-Gripp Syndrome

AYGRP	Cataracts, Congenital, With Sensorineural Deafness, Down Syndrome-Like Facial Appearance, Short Stature, And Mental Retardation
Aymé-Gripp Syndrome	Fine-Lubinsky Syndrome
Brachycephaly-Deafness-Cataract-Intellectual Disability Syndrome	Brachycephaly-Hearing Loss-Cataract-Intellectual Disability Syndrome

Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome	Duane'S Syndrome
Duane Syndrome	Isolated Duane Retraction Syndrome
Co-Contractive Retraction Syndrome	Duane Anomaly, Isolated
Ocular Retraction Syndrome	Drs
Durs

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12691	SERINC2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SERINC2	MGD	MGI:1919132
Bos taurus	SERINC2	VGNC	VGNC:106920
Macaca mulatta	SERINC2	VGNC	VGNC:77294
Canis familiaris	SERINC2	VGNC	VGNC:46020
Rattus norvegicus	SERINC2	RGD	RGD:1311396
Felis catus	SERINC2	VGNC	VGNC:65018

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