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ZACN - zinc activated ion channel Gene

Also Known as L2; ZAC; ZAC1; LGICZ; LGICZ1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 353174

About ZACN

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,079,182-76,082,806 (from NCBI)

This gene has 6 transcripts (splice variants), 111 orthologues and 45 paralogues. Ubiquitous expression in prostate (RPKM 23.1), brain (RPKM 20.2) and 25 other tissues.

Summary

LGICZ1 is a zinc-activated ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of ligand-gated ion channels (Davies et al., 2003 [PubMed 12381728]).[supplied by OMIM, Mar 2008]

ZACN Products (1)

mRNA	Protein	Name
NM_180990.4	NP_851321.2	zinc-activated ligand-gated ion channel precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ligand-gated monoatomic cation channel activity	IDA IDA: Inferred from direct assay	26872532	GOA
enables ligand-gated monoatomic ion channel activity	IDA IDA: Inferred from direct assay	12381728	GOA
enables pH-gated monoatomic ion channel activity	IDA IDA: Inferred from direct assay	26872532	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	12381728	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in monoatomic ion transmembrane transport	IDA IDA: Inferred from direct assay	12381728	GOA
involved in response to zinc ion	IDA IDA: Inferred from direct assay	12381728	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	16083862	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZACN Protein Structure

Neur_chan_LBD

0
100
200
300
412 a.a.

Protein Preferred Names	Protein Names
zinc-activated ligand-gated ion channel	ligand-gated ion channel subunit

Related Diseases

Diseases	Alias
Amme Complex	Alport Syndrome, Mental Retardation, Midface Hypoplasia, And Elliptocytosis ATS-MR Alport Syndrome-Intellectual Disability-Midface Hypoplasia-Elliptocytosis Syndrome Chromosome Xq22.3 Telomeric Deletion Syndrome Amme Syndrome Alport Syndrome With Intellectual Disability, Midface Hypoplasia And Elliptocytosis
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome
Hyperekplexia	Hereditary Hyperekplexia Kok Disease Congenital Stiff Man Syndrome Familial Startle Disease Sthe Stiff-Baby Syndrome Hereditary Hyperexplexia Startle Disease Exaggerated Startle Reaction Hyperexplexia Hereditary Startle Disease, Familial Startle Reaction, Exaggerated Stiff-Man Syndrome, Congenital Stiff-Person Syndrome, Congenital Congenital Stiff-Man Syndrome Congenital Stiff-Person Syndrome Familial Hyperekplexia Startle Syndrome Stiff Baby Syndrome Hyperekplexia, Hereditary Stiff-Person Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15949	ZACN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown