ZACN - zinc activated ion channel Gene

Homo sapiens

Also known as L2; ZAC; ZAC1; LGICZ; LGICZ1

Gene ID: 353174 | Gene type: protein coding

About ZACN

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,079,182-76,082,806 (from NCBI)

This gene has 6 transcripts (splice variants), 111 orthologues and 45 paralogues. Ubiquitous expression in prostate (RPKM 23.1), brain (RPKM 20.2) and 25 other tissues.

Summary

LGICZ1 is a zinc-activated ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of ligand-gated ion channels (Davies et al., 2003 [PubMed 12381728]).[supplied by OMIM, Mar 2008]

ZACN Products(1)

mRNA	Protein	Name
NM_180990.4	NP_851321.2	zinc-activated ligand-gated ion channel precursor

ZACN Protein Structure

Neur_chan_LBD

0
100
200
300
412 a.a.

Protein Preferred Names

Protein Names

zinc-activated ligand-gated ion channel

ligand-gated ion channel subunit

Related Diseases

Diseases

Alias

Amme Complex

Alport Syndrome, Mental Retardation, Midface Hypoplasia, And Elliptocytosis	ATS-MR
Alport Syndrome-Intellectual Disability-Midface Hypoplasia-Elliptocytosis Syndrome	Chromosome Xq22.3 Telomeric Deletion Syndrome
Amme Syndrome	Alport Syndrome With Intellectual Disability, Midface Hypoplasia And Elliptocytosis

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Hyperekplexia

Hereditary Hyperekplexia	Kok Disease
Congenital Stiff Man Syndrome	Familial Startle Disease
Sthe	Stiff-Baby Syndrome
Hereditary Hyperexplexia	Startle Disease
Exaggerated Startle Reaction	Hyperexplexia Hereditary
Startle Disease, Familial	Startle Reaction, Exaggerated
Stiff-Man Syndrome, Congenital	Stiff-Person Syndrome, Congenital
Congenital Stiff-Man Syndrome	Congenital Stiff-Person Syndrome
Familial Hyperekplexia	Startle Syndrome
Stiff Baby Syndrome	Hyperekplexia, Hereditary
Stiff-Person Syndrome