BMP8A - bone morphogenetic protein 8a Gene

Also Known as OP-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 353500

About BMP8A

This gene has 1 transcript (splice variant), 212 orthologues and 31 paralogues. Biased expression in thyroid (RPKM 57.4) and endometrium (RPKM 2.6).

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in development of the reproductive system. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016]

BMP8A Products (1)

mRNA Protein Name
NM_181809.4 NP_861525.2 bone morphogenetic protein 8A preproprotein

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in diet induced thermogenesis IDA
IDA: Inferred from direct assay
22579288 GOA
involved in energy homeostasis IDA
IDA: Inferred from direct assay
22579288 GOA
involved in negative regulation of insulin secretion IDA
IDA: Inferred from direct assay
22579288 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BMP8A Protein Structure

TGFb_propeptide

TGFb_propeptide: TGF-beta propeptide (34 - 251)

TGF_beta

TGF_beta: Transforming growth factor beta like domain (299 - 402)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
Protein Preferred Names Protein Names

bone morphogenetic protein 8A

  • BMP-8A

Recombinant BMP8A Proteins

Cat. No. Product Name Accession Purity
HY-P700031AF Animal-Free BMP-8a Protein, Human (His) AAP74559.1 (A264-H402) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Breast Giant Fibroadenoma

  • Giant Fibroadenoma

  • Giant Fibroadenoma Of Breast
Granulomatous Endometritis
Tympanosclerosis

  • Ts - [Tympanosclerosis]

  • Tympanic Membrane Sclerosis
Tympanic Membrane Disease

  • Disorder Of Tympanic Membrane
Microphthalmia, Isolated 4

  • Isolated Microphthalmia 4

  • MCOP4

  • Microphthalmia, Isolated, 4

  • Isolated Clinical Anophthalmia

  • Microphthalmia, Isolated, Type 4
Brachydactyly, Type A1, C

  • Brachydactyly Type A1c

  • BDA1C

  • Brachydactyly A1, C

  • Brachydactyly A1c

  • Brachydactyly Type A1 C
Leber Congenital Amaurosis 17

  • LCA17

  • Leber Congenital Amaurosis, Type 17
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01543 BMP8A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22407 Bmp8a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28931 Bmp8a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BMP8A MGD MGI:104515
Rattus norvegicus BMP8A RGD RGD:1585858