BMP8A - bone morphogenetic protein 8a Gene

Homo sapiens

Also known as OP-2

Gene ID: 353500 | Gene type: protein coding

About BMP8A

This gene has 1 transcript (splice variant), 212 orthologues and 31 paralogues. Biased expression in thyroid (RPKM 57.4) and endometrium (RPKM 2.6).

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in development of the reproductive system. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016]

BMP8A Products(1)

mRNA	Protein	Name
NM_181809.4	NP_861525.2	bone morphogenetic protein 8A preproprotein

BMP8A Protein Structure

TGFb_propeptide

TGF_beta

0
100
200
300
402 a.a.

Protein Preferred Names

Protein Names

bone morphogenetic protein 8A

BMP-8A

Recombinant BMP8A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79047	BMP-8a Protein, Human (CHO)	AAP74559 (A264-H402)	≥95%
HY-P700031AF	Animal-Free BMP-8a Protein, Human (His)	AAP74559.1 (A264-H402)	≥95%

Related Diseases

Diseases

Alias

Breast Giant Fibroadenoma

Giant Fibroadenoma

Giant Fibroadenoma Of Breast

Granulomatous Endometritis

Tympanosclerosis

Ts - [Tympanosclerosis]

Tympanic Membrane Sclerosis

Tympanic Membrane Disease

Disorder Of Tympanic Membrane

Microphthalmia, Isolated 4

Isolated Microphthalmia 4	MCOP4
Microphthalmia, Isolated, 4	Isolated Clinical Anophthalmia
Microphthalmia, Isolated, Type 4

Brachydactyly, Type A1, C

Brachydactyly Type A1c	BDA1C
Brachydactyly A1, C	Brachydactyly A1c
Brachydactyly Type A1 C

Leber Congenital Amaurosis 17

LCA17

Leber Congenital Amaurosis, Type 17

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01543	BMP8A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BMP8A	MGD	MGI:104515
Rattus norvegicus	BMP8A	RGD	RGD:1585858

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