Myo18a - myosin XVIIIA Gene

Also Known as MAJN; MyoPDZ; MysPDZ; SP-R210

Species: Mus musculus

Gene Type: protein coding
Gene ID: 360013

Summary

Predicted to enable ADP binding activity; ATP binding activity; and actin filament binding activity. Involved in positive regulation of opsonization and regulation of macrophage activation. Acts upstream of or within cellular response to interferon-gamma. Located in brush border; cytoskeleton; and phagocytic vesicle. Is expressed in several structures, including gonad; lower leg rest of mesenchyme; molar; nervous system; and skeletal musculature. Orthologous to human MYO18A (Myosin XVIIIA). [provided by Alliance of Genome Resources, Apr 2022]

Myo18a Products (5)

mRNA Protein Name
NM_001291212.1 NP_001278141.1 unconventional myosin-XVIIIa isoform 3
NM_001291213.1 NP_001278142.1 unconventional myosin-XVIIIa isoform 1
NM_001291214.1 NP_001278143.1 unconventional myosin-XVIIIa isoform 4
NM_001291215.1 NP_001278144.1 unconventional myosin-XVIIIa isoform 5
NM_011586.3 NP_035716.1 unconventional myosin-XVIIIa isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to type II interferon IDA
IDA: Inferred from direct assay
19144319 MGI
involved in positive regulation of opsonization IMP
IMP: Inferred from mutant phenotype
21123169 MGI
involved in regulation of macrophage activation IMP
IMP: Inferred from mutant phenotype
25965346 MGI
Cellular Component GO Annotation Evidence References Source
located in brush border IDA
IDA: Inferred from direct assay
22114352 MGI
located in cytoskeleton IDA
IDA: Inferred from direct assay
10733906 MGI
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
19144319 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

unconventional myosin-XVIIIa

  • molecule associated with JAK3 N-terminus

  • myosin XVIIIb

  • myosin containing a PDZ domain

  • surfactant protein receptor SP-R210

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08934 MYO18A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myo18a NCBI NCBI:399687