MYO18A - myosin XVIIIA Gene

Also Known as MAJN; TIAF1; MYSPDZ; SPR210; SP-R210

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 399687

About MYO18A

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:29,071,122-29,212,727 (from NCBI)

This gene has 25 transcripts (splice variants), 279 orthologues and 43 paralogues. Ubiquitous expression in skin (RPKM 21.0), bone marrow (RPKM 16.2) and 25 other tissues.

Summary

The protein encoded by this gene can bind GOLPH3, linking the Golgi to the Cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. [provided by RefSeq, Oct 2016]

MYO18A Products (6)

mRNA	Protein	Name
NM_001346765.2	NP_001333694.1	unconventional myosin-XVIIIa isoform c
NM_001346766.2	NP_001333695.1	unconventional myosin-XVIIIa isoform d
NM_001346767.2	NP_001333696.1	unconventional myosin-XVIIIa isoform e
NM_001346768.2	NP_001333697.1	unconventional myosin-XVIIIa isoform f
NM_078471.4	NP_510880.2	unconventional myosin-XVIIIa isoform a
NM_203318.2	NP_976063.1	unconventional myosin-XVIIIa isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ADP binding	IDA IDA: Inferred from direct assay	23990465	GOA
enables ATP binding	IDA IDA: Inferred from direct assay	23990465	GOA
NOT enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	23990465	GOA
enables actin filament binding	IDA IDA: Inferred from direct assay	23990465	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19837035	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	19837035	GOA
involved in Golgi ribbon formation	IMP IMP: Inferred from mutant phenotype	19837035	GOA
involved in Golgi vesicle budding	IMP IMP: Inferred from mutant phenotype	19837035	GOA
involved in actomyosin structure organization	IMP IMP: Inferred from mutant phenotype	18854160	GOA
involved in asymmetric Golgi ribbon formation	IMP IMP: Inferred from mutant phenotype	19837035	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	18854160	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	24485452	GOA
involved in positive regulation of opsonization	IMP IMP: Inferred from mutant phenotype	21123169	GOA
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	23345592	GOA
involved in regulation of macrophage activation	IMP IMP: Inferred from mutant phenotype	25965346	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in actomyosin	IDA IDA: Inferred from direct assay	18854160	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	19837035	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYO18A Protein Structure

PDZ

Myosin_head

Myosin_tail_1

0
400
800
1200
1600
2054 a.a.

Protein Preferred Names	Protein Names
unconventional myosin-XVIIIa	12 kDa TGF-beta-1-induced antiapoptotic factor

MYO18A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MYO18A	Q92614	GOLPH3	Homo sapiens	Q9H4A6	Pull Down	24485452
Intra	MYO18A	Q92614	GOLPH3	Homo sapiens	Q9H4A6	IF	19837035
Intra	MYO18A	Q92614	GOLPH3	Homo sapiens	Q9H4A6	Anti Bait CoIP	19837035
Intra	MYO18A	Q92614	GOLPH3	Homo sapiens	Q9H4A6	Anti Bait CoIP	24485452

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative	Atypical Chronic Myeloid Leukemia Atypical Chronic Myeloid Leukaemia Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Acml Atypical Chronic Myeloid Leukaemia Bcr-Abl1 Negative Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Atypical Cml Subacute Myeloid Leukemia Subacute Myelogenous Leukaemia Subacute Myeloid Leukaemia Subacute Myelosis Atypical Chronic Myeloid Leukaemia, Bcr-Abl-Negative Without Mention Of Remission Subacute Monocytic Leukaemia Without Mention Of Remission Subacute Monocytic Leukaemia
Chronic Tic Disorder	Chronic Motor Or Vocal Tic Disorder Tic Disorders Tic Disorder Tic Disorder Nos Tic Nos Tic Spasm Nos
Alzheimer Disease 18	AD18 Alzheimer'S Disease 18 Alzheimer Disease 18, Late-Onset Alzheimer Disease 18, Susceptibility To Alzheimer'S Disease 18, Late Onset Alzheimer Disease 18 Late-Onset Alzheimer Disease, Susceptibility To, Type 18
Developmental And Epileptic Encephalopathy 28	DEE28 Epileptic Encephalopathy, Early Infantile, 28 Eiee28 Developmental And Epileptic Encephalopathy, 28 Early Infantile Epileptic Encephalopathy 28 Encephalopathy, Epileptic, Early Infantile, Type 28
Intellectual Developmental Disorder, Autosomal Dominant 22	MRD22 Mental Retardation, Autosomal Dominant 22 Autosomal Dominant Non-Syndromic Intellectual Disability 22 Distal Monosomy 1q Autosomal Dominant Intellectual Developmental Disorder 22 Autosomal Dominant Mental Retardation 22 Distal Deletion 1q Monosomy 1qter Telomeric Deletion 1q Mental Retardation, Autosomal Dominant, Type 22
Developmental And Epileptic Encephalopathy 65	DEE65 Epileptic Encephalopathy, Early Infantile, 65 Eiee65 Developmental And Epileptic Encephalopathy, 65 Early Infantile Epileptic Encephalopathy 65 Encephalopathy, Epileptic, Early Infantile, Type 65
Developmental And Epileptic Encephalopathy 84	DEE84 Jamuar Syndrome Eiee84 Developmental And Epileptic Encephalopathy, 84 Epileptic Encephalopathy, Early Ifantile, 84 Early Infantile Epileptic Encephalopathy 84 Epileptic Encephalopathy, Early Infantile, 84 Encephalopathy, Epileptic, Early Infantile, Type 84
Infancy Electroclinical Syndrome
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Spinocerebellar Ataxia, Autosomal Recessive 12	Autosomal Recessive Spinocerebellar Ataxia 12 SCAR12 Spinocerebellar Ataxia With Mental Retardation And Epilepsy Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Wwox Deficiency Autosomal Recessive Spinocerebellar Ataxia Type 12 Spinocerebellar Ataxia, Autosomal Recessive, 12 Ataxia, Spinocerebellar, Autosomal Recessive, Type 12
West Syndrome	Infantile Spasms Infantile Spasms Syndrome Infantile Spasm X-Linked Infantile Spasm Syndrome X-Linked Infantile Spasms Epileptic Encephalopathy, Early Infantile, 1 Is Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg West'S Syndrome Spasms, Infantile Is -[Infantile Spasm] Salaam Spasm Salaam Tic
Early Infantile Epileptic Encephalopathy	Early Infantile Epileptic Encephalopathy With Burst-Suppression Early Infantile Epileptic Encephalopathy With Suppression Bursts Eiee Early Infantile Epileptic Encephalopathy With Suppression-Bursts Ohtahara Syndrome Encephalopathy, Epileptic, Early Infantile
Bardet-Biedl Syndrome 1	BBS1 Bardet-Biedl Syndrome 1, Modifier Of Bardet-Biedl Syndrome BBS Bardet-Biedl Syndrome, Type 1 Laurence-Moon-Bardet-Biedl Syndrome
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Developmental And Epileptic Encephalopathy	Encephalopathy, Developmental And Epileptic
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08934	MYO18A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MYO18A	VGNC	VGNC:31813
Macaca mulatta	MYO18A	VGNC	VGNC:75058
Felis catus	MYO18A	VGNC	VGNC:63685
Mus musculus	MYO18A	MGD	MGI:2667185
Rattus norvegicus	MYO18A	RGD	RGD:1562698
Canis familiaris	MYO18A	VGNC	VGNC:43557
Others	MYO18A	NCBI