IMPG1 - interphotoreceptor matrix proteoglycan 1 Gene

Also Known as RP91; VMD4; GP147; SPACR; IPM150

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3617

About IMPG1

Cytogenetic location: 6q14.1 Genomic coordinates (GRCh38): 6:75,921,114-76,072,662 (from NCBI)

This gene has 4 transcripts (splice variants), 263 orthologues, 1 paralogue and is associated with 6 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a protein that is a major component of the retinal interphotoreceptor matrix. The encoded protein is a proteoglycan that is thought to play a role in maintaining viability of photoreceptor cells and in adhesion of the neural retina to the retinal pigment epithelium. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

IMPG1 Products (2)

mRNA Protein Name
NM_001282368.2 NP_001269297.1 interphotoreceptor matrix proteoglycan 1 isoform 2 precursor
NM_001563.4 NP_001554.2 interphotoreceptor matrix proteoglycan 1 isoform 1 precursor

IMPG1 Protein Structure

SEA

SEA: SEA domain (233 - 335)

SEA

SEA: SEA domain (574 - 674)

  • 0
  • 200
  • 400
  • 600
  • 797 a.a.
Protein Preferred Names Protein Names

interphotoreceptor matrix proteoglycan 1

  • interphotoreceptor matrix proteoglycan of 150 kDa

Related Diseases

Diseases Alias
Macular Dystrophy, Vitelliform, 4

  • VMD4

  • Vitelliform Macular Dystrophy 4
Retinitis Pigmentosa 91

  • Benign Concentric Annular Macular Dystrophy

  • RP91

  • Macular Dystrophy, Concentric Annular, Formerly

  • Mcdca, Formerly

  • Macular Dystrophy, Benign Concentric Annular, Formerly

  • Bcamd, Formerly

  • Bcamd

  • Macular Dystrophy, Benign Concentric Annular

  • Macular Dystrophy, Concentric Annular

  • Mcdca

  • Retinitis Pigmentosa, Type 91
Vitelliform Macular Dystrophy

  • Best Disease

  • Juvenile-Onset Vitelliform Macular Dystrophy

  • Macular Dystrophy, Vitelliform

  • Best Macular Dystrophy

  • Vitelliform Dystrophy
Macular Dystrophy, Vitelliform, 3

  • Adult-Onset Vitelliform Macular Dystrophy

  • Avmd

  • Adult-Onset Foveomacular Vitelliform Dystrophy

  • Aofmd

  • VMD3

  • Vitelliform Macular Dystrophy, Adult-Onset

  • Foveomacular Dystrophy, Adult-Onset, With Or Without Choroidal Neovascularization

  • Foveomacular Dystrophy, Adult-Onset, With Choroidal Neovascularization

  • Adult-Onset Foveomacular Dystrophy

  • Vitelliform Macular Dystrophy 3

  • Foveomacular Dystrophy, Adult-Onset

  • Foveomacular Dystrophy, Adult-Onset

  • Aofmd

  • Macular Dystrophy, Vitelliform, Adult-Onset

  • Adult-Onset Foveomacular Dystrophy With Choroidal Neovascularization

  • Gass Disease

  • Pseudo-Best Disease

  • Pseudo-Vitelliform Macular Dystrophy

  • Gas
Macular Dystrophy, Vitelliform, 2

  • Best Macular Dystrophy

  • Juvenile-Onset Vitelliform Macular Dystrophy

  • VMD2

  • Bmd

  • Macular Degeneration, Polymorphic Vitelline

  • Best Vitelliform Macular Dystrophy

  • Best Disease

  • Early-Onset Vitelliform Macular Dystrophy

  • Best Vitelliform Macular Dystrophy, Multifocal

  • Bvmd

  • Polymorphic Vitelline Macular Degeneration

  • Vitelliform Macular Dystrophy Type 2

  • Vitelliform Macular Dystrophy 2

  • Vitelliform Macular Dystrophy, Early-Onset

  • Vitelliform Macular Dystrophy, Juvenile-Onset

  • Autosomal Recessive Bestrophinopathy

  • Retinopathy, Burgess-Black Type

  • Best'S Macular Dystrophy

  • Vmd

  • Vitelliform Macular Dystrophy
Isolated Macular Dystrophy
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Macular Dystrophy, Concentric Annular

  • Mcdca

  • Maculopathy, Bull'S Eye
Retinal Disease

  • Retinal Diseases

  • Retinal Disorder

  • Retinal Disorders
Kahrizi Syndrome

  • KHRZ

  • Mental Retardation, Cataract, Coloboma, And Kyphosis, Autosomal Recessive

  • Intellectual Disability, Kahrizi Type

  • Intellectual Disability-Cataract-Coloboma-Kyphosis Syndrome
Fundus Dystrophy

  • Retinal Dystrophy

  • Retinal Dystrophies

  • Dystrophy, Retinal
Cone-Rod Dystrophy 3

  • CORD3

  • Dystrophy, Cone Rod, Type 3
Bestrophinopathy, Autosomal Recessive

  • Bestrophinopathy

  • Autosomal Recessive Bestrophinopathy

  • ARB

  • Bestrophinopathies

  • Retinopathy, Burgess-Black Type

  • Retinopathy Burgess-Black Type
Nasal Cavity Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Nasal Cavity

  • Squamous Cell Carcinoma Of The Nasal Cavity
Cone-Rod Dystrophy 7

  • CORD7

  • Dystrophy, Cone-Rod, Type 7

  • Retinitis Pigmentosa 7
Vitreoretinochoroidopathy

  • Autosomal Dominant Vitreoretinochoroidopathy

  • Advirc

  • Vitreoretinochoroidopathy With Microcornea, Glaucoma, And Cataract

  • Vitreoretinochoroidopathy, Autosomal Dominant, With Nanophthalmos

  • Microcornea, Rod-Cone Dystrophy, Cataract, And Posterior Staphyloma 2

  • Vitreoretinochoroidopathy Dominant

  • VRCP

  • Vitreoretinochoroidopathy, Autosomal Dominant

  • Vrcp Autosomal Dominant

  • Vitreoretinochoroidopathy Autosomal Dominant With Nanophthalmos, Microcornea, Rod-Cone Dystrophy, Cataract And Posterior Staphyloma

  • Vitreoretinochoroidopathy With Microcornea-Glaucoma-Cataract
Basal Laminar Drusen

  • Drusen Of Bruch Membrane

  • Drusen, Cuticular

  • Drusen, Early Adult-Onset, Grouped

  • Cuticular Drusen

  • Early Adult-Onset Grouped Drusen

  • BLD

  • Drusen Cuticular

  • Drusen Early Adult-Onset Grouped
Macular Degeneration, Age-Related, 1

  • Macular Degeneration

  • Age-Related Macular Degeneration

  • Macular Degeneration, Age-Related

  • Age Related Macular Degeneration

  • Age Related Macular Degeneration 1

  • ARMD1

  • Senile Macular Degeneration

  • Maculopathy, Age-Related, 1

  • Macular Degeneration, Age-Related, Reduced Risk Of

  • Age Related Maculopathy 1

  • Age Related Maculopathies

  • Age Related Maculopathy

  • Senile Macular Retinal Degeneration

  • Macular Degeneration Of Retina

  • Age-Related Maculopathy

  • Amd

  • Armd

  • Age-Related Maculopathy, Susceptibility To

  • Maculopathy Age-Related

  • Macular Degeneration, Age-Related, 1, Susceptibility To

  • Maculopathy, Age-Related

  • Macular Degeneration, Age-Related, Type 1

  • Macular Degeneration, Age-Related, 2
Stargardt Disease

  • Stargardt Disease 1

  • Stargardt Macular Dystrophy

  • Stargardt Disease-1

  • Juvenile Onset Macular Degeneration

  • Stargardt Macular Degeneration

  • Juvenile Macular Degeneration

  • Macular Dystrophy With Flecks, Type 1

  • Stgd

  • Fundus Flavimaculatus

  • Stargardt 1

  • Stargardts Disease
Congenital Stationary Night Blindness

  • Night Blindness, Congenital Stationary

  • Congenital Essential Nyctalopia

  • Oguchi Disease

  • Blindness, Night, Stationary, Congenital
Leber Plus Disease

  • Leber Congenital Amaurosis

  • Lca

  • Leber'S Amaurosis

  • Leber'S Disease

  • Amaurosis Congenita Of Leber

  • Amaurosis Congenita Of Leber, Type 1

  • Lhon Plus Disease

  • Congenital Absence Of The Rods And Cones

  • Congenital Retinal Blindness

  • Crb

  • Congenital Amaurosis Of Retinal Origin

  • Leber'S Congenital Amaurosis

  • Leber Congenital Amaurosis 1

  • Leber'S Congenital Tapetoretinal Degeneration

  • Leber'S Congenital Tapetoretinal Dysplasia

  • Lca1

  • Leber Congenital Amaurosis Type 1

  • Retinal Blindness, Congenital

  • Amaurosis, Leber Congenital

  • Dysgenesis Neuroepithelialis Retinae

  • Hereditary Epithelial Dysplasia Of Retina

  • Hereditary Retinal Aplasia

  • Heredoretinopathia Congenitalis

  • Leber Abiotrophy

  • Leber Congenital Tapetoretinal Degeneration

  • Lebers Congenital Amaurosis

  • Optic Atrophy, Hereditary, Leber
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06800 IMPG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta IMPG1 VGNC VGNC:104405
Mus musculus IMPG1 MGD MGI:1926876
Canis familiaris IMPG1 VGNC VGNC:42012
Rattus norvegicus IMPG1 RGD RGD:620499
Felis catus IMPG1 VGNC VGNC:67799
Others IMPG1 NCBI