2. Gene
  3. PTPRT - Ptprt protein tyrosine phosphatase, receptor type, T Gene

PTPRT - Ptprt protein tyrosine phosphatase, receptor type, T Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 362263 | Gene type: protein coding

About PTPRT

Summary

Predicted to enable several functions, including STAT family protein binding activity; alpha-catenin binding activity; and beta-catenin binding activity. Involved in regulation of synapse organization. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in colorectal Cancer and esophagus squamous cell carcinoma. Orthologous to human PTPRT (protein tyrosine Phosphatase receptor type T). [provided by Alliance of Genome Resources, Apr 2022]

PTPRT Products(2)

mRNA Protein Name
NM_001108603.2 NP_001102073.2 receptor-type tyrosine-protein phosphatase T isoform 1 precursor
NM_001402009.1 NP_001388938.1 receptor-type tyrosine-protein phosphatase T isoform 2 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in regulation of synapse organization IDA
IDA: Inferred from direct assay
19816407 RGD
involved in regulation of synapse organization IMP
IMP: Inferred from mutant phenotype
19816407 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19816407 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
19816407 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
19816407 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase T

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-183573 PTPRO-IN-1 Inhibitor / Unkown
HY-RS11450 PTPRT Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PTPRT NCBI NCBI:11122