2. Gene
  3. PTPRT - protein tyrosine phosphatase receptor type T Gene

PTPRT - protein tyrosine phosphatase receptor type T Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as R-PTP-T; RPTPrho; RPTP-rho

Gene ID: 11122 | Gene type: protein coding

About PTPRT

Cytogenetic location: 20q12-q13.11 Genomic coordinates (GRCh38): 20:42,031,890-43,189,906 (from NCBI)

This gene has 12 transcripts (splice variants), 221 orthologues, 35 paralogues and is associated with 128 phenotypes. Biased expression in brain (RPKM 9.9) and placenta (RPKM 1.1).

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

PTPRT Products(5)

mRNA Protein Name
NM_001394024.1 NP_001380953.1 receptor-type tyrosine-protein phosphatase T isoform 3 precursor
NM_001394025.1 NP_001380954.1 receptor-type tyrosine-protein phosphatase T isoform 4 precursor
NM_001394026.1 NP_001380955.1 receptor-type tyrosine-protein phosphatase T isoform 5 precursor
NM_007050.6 NP_008981.4 receptor-type tyrosine-protein phosphatase T isoform 2 precursor
NM_133170.4 NP_573400.3 receptor-type tyrosine-protein phosphatase T isoform 1 precursor

PTPRT Protein Structure

MAM

MAM: MAM domain, meprin/A5/mu (32 - 191)

fn3

fn3: Fibronectin type III domain (296 - 372)

fn3

fn3: Fibronectin type III domain (501 - 577)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (931 - 1161)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (1221 - 1455)

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  • 1460 a.a.
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase T

receptor protein tyrosine phosphatase

Related Diseases

Diseases Alias
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11450 PTPRT Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PTPRT MGD MGI:1321152
Macaca mulatta PTPRT VGNC VGNC:76623
Bos taurus PTPRT VGNC VGNC:57018
Felis catus PTPRT VGNC VGNC:69182
Rattus norvegicus PTPRT RGD RGD:1309653
Canis familiaris PTPRT VGNC VGNC:45199