Pnpla3 - patatin-like phospholipase domain containing 3 Gene

Also Known as Adpn

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 362972

Summary

Predicted to enable several functions, including acylglycerol O-acyltransferase activity; Lipase activity; and long-chain fatty acyl-CoA binding activity. Involved in cellular response to organonitrogen compound; response to sucrose; and white fat cell differentiation. Predicted to be active in cytoplasm; lipid droplet; and membrane. Biomarker of hypothyroidism and obesity. Human ortholog(s) of this gene implicated in coronary artery disease; fatty liver disease (multiple); liver disease (multiple); and type 2 diabetes mellitus. Orthologous to human PNPLA3 (patatin like Phospholipase domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Pnpla3 Products (1)

mRNA Protein Name
NM_001282324.1 NP_001269253.1 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to 3,3',5-triiodo-L-thyronine IEP
IEP: Inferred from expression pattern
19619606 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
19619606 RGD
involved in response to sucrose IEP
IEP: Inferred from expression pattern
12565853 RGD
involved in white fat cell differentiation IEP
IEP: Inferred from expression pattern
19619606 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

1-acylglycerol-3-phosphate O-acyltransferase PNPLA3

  • adiponutrin

  • patatin-like phospholipase domain-containing protein 3

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-163959 PF-07853578 Modulator 99.08% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N1967 Dihydrocurcumin Modulator 99.58% Unkown
HY-177628 Edutirsen Inhibitor 98.52% Unkown
HY-RS10794 PNPLA3 Human Pre-designed siRNA Set A / Unkown
HY-173599 NUV-244 Inhibitor / Unkown
HY-177628A Edutirsen sodium Inhibitor / Unkown
HY-159656 PNPLA3 modifier 1 Modulator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pnpla3 NCBI NCBI:80339