Traip - TRAF-interacting protein Gene

Predicted to enable identical protein binding activity and ubiquitin protein Ligase activity. Predicted to be involved in several processes, including negative regulation of interferon-beta production; negative regulation of tumor necrosis factor-mediated signaling pathway; and replication fork processing. Predicted to act upstream of or within negative regulation of NF-kappaB transcription factor activity and signal transduction. Predicted to be located in nucleolus; nucleoplasm; and site of DNA damage. Human ortholog(s) of this gene implicated in Seckel syndrome 9. Orthologous to human TRAIP (TRAF interacting protein). [provided by Alliance of Genome Resources, Apr 2022]