TRAIP - TRAF interacting protein Gene

Also Known as TRIP; SCKL9; RNF206

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10293

About TRAIP

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,828,601-49,856,564 (from NCBI)

This gene has 11 transcripts (splice variants), 198 orthologues and is associated with 3 phenotypes. Broad expression in testis (RPKM 4.0), bone marrow (RPKM 2.3) and 23 other tissues.

Summary

This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against Apoptosis. [provided by RefSeq, Jul 2008]

TRAIP Products (1)

mRNA Protein Name
NM_005879.3 NP_005870.2 E3 ubiquitin-protein ligase TRAIP

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17474147 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
17544371 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
26711499 GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway IDA
IDA: Inferred from direct assay
19151749 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
17544371 GOA
involved in replication fork processing IDA
IDA: Inferred from direct assay
26711499 GOA
involved in replication fork processing IMP
IMP: Inferred from mutant phenotype
27462463 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
27462463 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
30165463 GOA
located in site of DNA damage IDA
IDA: Inferred from direct assay
26711499 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAIP Protein Structure

zf-RING_2

zf-RING_2: Ring finger domain (7 - 50)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 469 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRAIP

  • RING-type E3 ubiquitin transferase TRAIP

TRAIP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRAIP Q9BWF2 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
TRAIP Q9BWF2 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
TRAIP Q9BWF2 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
TRAIP Q9BWF2 MAPRE2 Homo sapiens Q15555
Validated Y2H
25416956
Intra
TRAIP Q9BWF2 MAPRE2 Homo sapiens Q15555
Y2H Array
32296183
Intra
TRAIP Q9BWF2 MAPRE2 Homo sapiens Q15555
Y2H Prey Pooling
25416956
Intra
TRAIP Q9BWF2 MAPRE2 Homo sapiens Q15555
Y2H Prey Pooling
32296183
Intra
TRAIP Q9BWF2 ccsb_9919 Homo sapiens EBI-25847655
Y2H Array
32814053
Intra
TRAIP Q9BWF2 UBE2K Homo sapiens P61086
Y2H Array
32814053
Intra
TRAIP Q9BWF2 UBE2K Homo sapiens P61086
Y2H Pooling
32814053
Intra
TRAIP Q9BWF2 UBE2K Homo sapiens P61086
Validated Y2H
32814053
Intra
TRAIP Q9BWF2 MAPRE3 Homo sapiens Q9UPY8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Seckel Syndrome 9

  • SCKL9
Seckel Syndrome

  • Microcephalic Primordial Dwarfism

  • Bird-Headed Dwarfism

  • Harper'S Syndrome

  • Virchow-Seckel Dwarfism

  • Nanocephalic Dwarfism

  • Sckl

  • Seckel-Type Dwarfism
Inflammatory Bowel Disease 9

  • IBD9
Meier-Gorlin Syndrome 8

  • MGORS8
Deafness, Autosomal Dominant 70

  • DFNA70

  • Autosomal Dominant Nonsyndromic Deafness 70

  • Autosomal Dominant Deafness 70

  • Deafness, Autosomal Dominant, 70
Ruijs-Aalfs Syndrome

  • Progeroid Features-Hepatocellular Carcinoma Predisposition Syndrome

  • RJALS
Spiradenoma

  • Eccrine Spiradenoma

  • Benign Eccrine Spiradenoma

  • Eccrine Spiradenoma Of Skin

  • Es

  • Eccrine Spiradenoma, Benign
Isolated Growth Hormone Deficiency, Type Ia

  • Ighd Ia

  • Primordial Dwarfism

  • Isolated Growth Hormone Deficiency Type Ia

  • Sexual Ateleiotic Dwarfism

  • Pituitary Dwarfism I

  • IGHD1A

  • Illig-Type Growth Hormone Deficiency

  • Growth Hormone Deficiency, Isolated, Type Ia

  • Congenital Ighd Type Ia

  • Congenital Isolated Gh Deficiency Type Ia

  • Congenital Isolated Growth Hormone Deficiency Type Ia

  • Pituitary Dwarfism 1

  • Growth Hormone Deficiency, Isolated, Autosomal Recessive

  • Autosomal Recessive Isolated Growth Hormone Deficiency

  • Isolated Growth Hormone Deficiency Type 1a

  • Congenital Ighd

  • Congenital Isolated Gh Deficiency

  • Congenital Isolated Growth Hormone Deficiency

  • Growth Hormone Deficiency, Isolated Autosomal Recessive

  • Illig Type Growth Hormone Deficiency

  • Non-Acquired Isolated Growth Hormone Deficiency

  • Growth Hormone Deficiency, Isolated, 1a

  • Growth Hormone Deficiency Isolated Autosomal Recessive

  • Dwarfism, Primordial

  • Dwarfism
Brooke-Spiegler Syndrome

  • Cyld Cutaneous Syndrome

  • Spiegler-Brooke Syndrome

  • Familial Cylindromatosis

  • BRSS

  • Bss

  • Sbs

  • Multiple Familial Trichoepithelioma

  • Ancell-Spiegler Cylindromas

  • Familial Multiple Trichoepithelioma

  • Trichoepithelioma

  • Fc

  • Mft

  • Multiple Familial Trichoepitheliomas

  • Ccs

  • Turban Tumor Syndrome

  • Schilbach-Rott Syndrome

  • Eccrine Dermal Cylindroma

  • Familial Multiple Trichoepitheliomata
Meier-Gorlin Syndrome 1

  • Meier-Gorlin Syndrome

  • Ear, Patella, Short Stature Syndrome

  • Microtia, Absent Patellae, Micrognathia Syndrome

  • MGORS1

  • Eps

  • Ear-Patella-Short Stature Syndrome

  • Ear Patella Short Stature Syndrome

  • Microtia Absent Patellae Micrognathia Syndrome

  • Meier-Gorlin Syndrome, Type 1
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14978 TRAIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TRAIP MGD MGI:1096377
Felis catus TRAIP VGNC VGNC:66504
Macaca mulatta TRAIP VGNC VGNC:82261
Bos taurus TRAIP VGNC VGNC:36280
Canis familiaris TRAIP VGNC VGNC:47772
Rattus norvegicus TRAIP RGD RGD:1309761
Others TRAIP NCBI