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MAPRE2 - microtubule associated protein RP/EB family member 2 Gene

Also Known as EB1; EB2; RP1; CSCSC2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10982

About MAPRE2

Cytogenetic location: 18q12.1-q12.2 Genomic coordinates (GRCh38): 18:34,977,027-35,143,470 (from NCBI)

This gene has 13 transcripts (splice variants), 216 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 59.8), heart (RPKM 31.4) and 24 other tissues.

Summary

The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during Mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

MAPRE2 Products (4)

mRNA	Protein	Name
NM_001143826.3	NP_001137298.1	microtubule-associated protein RP/EB family member 2 isoform 2
NM_001143827.3	NP_001137299.1	microtubule-associated protein RP/EB family member 2 isoform 3
NM_001256420.2	NP_001243349.1	microtubule-associated protein RP/EB family member 2 isoform 4
NM_014268.4	NP_055083.1	microtubule-associated protein RP/EB family member 2 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	25490267	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in focal adhesion	IDA IDA: Inferred from direct assay	25490267	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPRE2 Protein Structure

EB1

0
100
200
300
327 a.a.

Protein Preferred Names	Protein Names
microtubule-associated protein RP/EB family member 2	APC-binding protein EB1

MAPRE2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAPRE2	Q15555	MAPRE1	Homo sapiens	Q15691	Validated Y2H	32296183
Intra	MAPRE2	Q15555	MAPRE1	Homo sapiens	Q15691	Y2H Array	25416956
Intra	MAPRE2	Q15555	MAPRE1	Homo sapiens	Q15691	TAP	27173435
Intra	MAPRE2	Q15555	MAPRE1	Homo sapiens	Q15691	Y2H Prey Pooling	25416956
Intra	MAPRE2	Q15555	MAPRE1	Homo sapiens	Q15691	Validated Y2H	25416956
Intra	MAPRE2	Q15555	CRTAC1	Homo sapiens	Q9NQ79	Y2H Array	32296183
Intra	MAPRE2	Q15555	CRTAC1	Homo sapiens	Q9NQ79	Validated Y2H	32296183
Intra	MAPRE2	Q15555	CRTAC1	Homo sapiens	Q9NQ79	Y2H Prey Pooling	25416956
Intra	MAPRE2	Q15555	CRTAC1	Homo sapiens	Q9NQ79	Y2H Prey Pooling	32296183
Intra	MAPRE2	Q15555	PAXIP1	Homo sapiens	Q6ZW49-2	Y2H Prey Pooling	25416956
Intra	MAPRE2	Q15555	PAXIP1	Homo sapiens	Q6ZW49-2	Validated Y2H	25416956
Intra	MAPRE2	Q15555	PAXIP1	Homo sapiens	Q6ZW49-2	Y2H Array	25416956
Intra	MAPRE2	Q15555	LMO2	Homo sapiens	P25791-3	Y2H Array	32296183
Intra	MAPRE2	Q15555	LMO2	Homo sapiens	P25791-3	Y2H Prey Pooling	32296183
Intra	MAPRE2	Q15555	RBM6	Homo sapiens	P78332-2	Y2H Prey Pooling	32296183
Intra	MAPRE2	Q15555	RBM6	Homo sapiens	P78332-2	Y2H Array	32296183
Intra	MAPRE2	Q15555	TRAIP	Homo sapiens	Q9BWF2	Y2H Array	31515488
Intra	MAPRE2	Q15555	TRAIP	Homo sapiens	Q9BWF2	Validated Y2H	32296183
Intra	MAPRE2	Q15555	TRAIP	Homo sapiens	Q9BWF2	Y2H Prey Pooling	32296183
Intra	MAPRE2	Q15555	TRAIP	Homo sapiens	Q9BWF2	Y2H Array	32296183
Intra	MAPRE2	Q15555	TRAIP	Homo sapiens	Q9BWF2	Y2H Array	25416956
Intra	MAPRE2	Q15555	TXN2	Homo sapiens	Q99757	Y2H Prey Pooling	25416956
Intra	MAPRE2	Q15555	TXN2	Homo sapiens	Q99757	Validated Y2H	32296183
Intra	MAPRE2	Q15555	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	MAPRE2	Q15555	TRAF1	Homo sapiens	Q13077	Validated Y2H	27107012
Intra	MAPRE2	Q15555	TRAF1	Homo sapiens	Q13077	BFG-2H	27107012
Intra	MAPRE2	Q15555	TRAF1	Homo sapiens	Q13077	Validated Y2H	25416956
Intra	MAPRE2	Q15555	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	MAPRE2	Q15555	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	25416956
Intra	MAPRE2	Q15555	MAPRE3	Homo sapiens	Q9UPY8	Y2H Pooling	16189514
Intra	MAPRE2	Q15555	MAPRE3	Homo sapiens	Q9UPY8	MAPPIT	32296183
Intra	MAPRE2	Q15555	MAPRE3	Homo sapiens	Q9UPY8	Validated Y2H	32296183
Intra	MAPRE2	Q15555	MAPRE3	Homo sapiens	Q9UPY8	Anti Tag CoIP	33961781
Intra	MAPRE2	Q15555	MAPRE3	Homo sapiens	Q9UPY8	Complementation	32296183
Intra	MAPRE2	Q15555	LMO2	Homo sapiens	P25791	Y2H Array	25416956
Intra	MAPRE2	Q15555	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	MAPRE2	Q15555	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	MAPRE2	Q15555	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	MAPRE2	Q15555	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	MAPRE2	Q15555	GAS2L2	Homo sapiens	Q8NHY3	Validated Y2H	32296183
Intra	MAPRE2	Q15555	GAS2L2	Homo sapiens	Q8NHY3	Y2H Prey Pooling	32296183
Intra	MAPRE2	Q15555	GAS2L2	Homo sapiens	Q8NHY3	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Skin Creases, Congenital Symmetric Circumferential, 2	CSCSC2 Symmetric Circumferential Skin Creases, Congenital, 2 Congenital Symmetric Circumferential Skin Creases 2
Multiple Benign Circumferential Skin Creases On Limbs	Ccsf Circumferential Skin Creases, Kunze Type Congenital Circumferential Skin Folds Kunze-Riehm Syndrome Kunze Riehm Syndrome Michelin Tire Baby Syndrome
Autosomal Dominant Intellectual Developmental Disorder 8	Autosomal Dominant Non-Syndromic Intellectual Disability 8 Mental Retardation, Autosomal Dominant 8 Autosomal Dominant Mental Retardation 8 Mrd8
Skin Creases, Congenital Symmetric Circumferential, 1	Michelin Tire Baby Syndrome CSCSC1 Skin Creases, Multiple Benign Ring-Shaped, Of Limbs Circumferential Skin Creases, Kunze Type Congenital Symmetric Circumferential Skin Creases 1 Circumferential Skin Creases Kunze Type Symmetric Circumferential Skin Creases, Congenital, 1 Csc-Kt Multiple Benign Ring-Shaped Skin Creases Of Limbs Michelin-Tire Baby
Severe Congenital Neutropenia 6	Autosomal Recessive Severe Congenital Neutropenia Due To Jagn1 Deficiency Scn6
Vexas Syndrome	VEXAS Vexas Syndrome, Somatic Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory And Somatic Syndrome Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic Syndrome Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic
Simultanagnosia
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08138	MAPRE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MAPRE2	VGNC	VGNC:31233
Macaca mulatta	MAPRE2	VGNC	VGNC:74656
Felis catus	MAPRE2	VGNC	VGNC:68180
Mus musculus	MAPRE2	MGD	MGI:106271
Rattus norvegicus	MAPRE2	RGD	RGD:1590736
Canis familiaris	MAPRE2	VGNC	VGNC:43010
Others	MAPRE2	NCBI