SLC27A1 - solute carrier family 27 member 1 Gene

Also Known as FATP; FATP1; ACSVL5; FATP-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 376497

About SLC27A1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,468,767-17,506,168 (from NCBI)

This gene has 9 transcripts (splice variants), 279 orthologues and 12 paralogues. Ubiquitous expression in ovary (RPKM 10.2), fat (RPKM 9.1) and 24 other tissues.

Summary

Enables biotin transmembrane transporter activity; efflux transmembrane transporter activity; and long-chain fatty acid transporter activity. Involved in several processes, including carboxylic acid transmembrane transport; glycerophospholipid biosynthetic process; and lipid transport across blood-brain barrier. Located in membrane. Part of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC27A1 Products (1)

mRNA Protein Name
NM_198580.3 NP_940982.1 long-chain fatty acid transport protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables biotin transmembrane transporter activity IDA
IDA: Inferred from direct assay
28035674 GOA
enables efflux transmembrane transporter activity IDA
IDA: Inferred from direct assay
28035674 GOA
enables efflux transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
31091338 GOA
enables long-chain fatty acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
28035674 GOA
enables long-chain fatty acid transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
21395585 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28178239 GOA
Biological Process GO Annotation Evidence References Source
involved in biotin import across plasma membrane IDA
IDA: Inferred from direct assay
28035674 GOA
involved in biotin transport IDA
IDA: Inferred from direct assay
28035674 GOA
involved in cardiolipin biosynthetic process IMP
IMP: Inferred from mutant phenotype
19523918 GOA
involved in export across plasma membrane IDA
IDA: Inferred from direct assay
28035674 GOA
involved in export across plasma membrane IMP
IMP: Inferred from mutant phenotype
31091338 GOA
involved in lipid transport across blood-brain barrier IMP
IMP: Inferred from mutant phenotype
21395585 GOA
involved in long-chain fatty acid import across plasma membrane IDA
IDA: Inferred from direct assay
28035674 GOA
involved in long-chain fatty acid import across plasma membrane IMP
IMP: Inferred from mutant phenotype
28035674 GOA
involved in long-chain fatty acid import into cell IMP
IMP: Inferred from mutant phenotype
28178239 GOA
involved in long-chain fatty acid transport IDA
IDA: Inferred from direct assay
28035674 GOA
involved in long-chain fatty acid transport IMP
IMP: Inferred from mutant phenotype
21395585 GOA
involved in negative regulation of phospholipid biosynthetic process IMP
IMP: Inferred from mutant phenotype
19523918 GOA
involved in phosphatidic acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
19523918 GOA
involved in phosphatidylcholine biosynthetic process IMP
IMP: Inferred from mutant phenotype
19523918 GOA
involved in phosphatidylethanolamine biosynthetic process IMP
IMP: Inferred from mutant phenotype
19523918 GOA
involved in phosphatidylglycerol biosynthetic process IMP
IMP: Inferred from mutant phenotype
19523918 GOA
involved in phosphatidylinositol biosynthetic process IMP
IMP: Inferred from mutant phenotype
19523918 GOA
involved in phosphatidylserine biosynthetic process IMP
IMP: Inferred from mutant phenotype
19523918 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
28035674 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC27A1 Protein Structure

AMP-binding

AMP-binding: AMP-binding enzyme (82 - 515)

AMP-binding_C

AMP-binding_C: AMP-binding enzyme C-terminal domain (523 - 598)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 646 a.a.
Protein Preferred Names Protein Names

long-chain fatty acid transport protein 1

  • arachidonate--CoA ligase

Related Diseases

Diseases Alias
Ichthyosis Prematurity Syndrome

  • IPS

  • Ichthyosis Congenita Iv

  • Ichthyosis-Prematurity Syndrome

  • Congenital Ichthyosis Type 4
Lethal Restrictive Dermopathy

  • Hyperkeratosis-Contracture Syndrome

  • Tight Skin Contracture Syndrome

  • Tight Skin Contracture Syndrome, Lethal

  • Dermopathy, Restrictive, Lethal
Platelet Glycoprotein Iv Deficiency

  • Platelet-Type Bleeding Disorder 10

  • Bdplt10

  • Cd36 Deficiency

  • Bleeding Disorder, Platelet-Type, 10

  • PG4D

  • Bleeding Disorder Platelet-Type 10

  • Deficiency, Platelet Glycoprotein Iv
Melkersson-Rosenthal Syndrome

  • Melkersson Syndrome

  • Mros

  • Mrs

  • Cheilitis Granulomatosa Of Mescher-Melkersson-Rosenthal

  • Melkersson'S Syndrome

  • Cheilitis Granulomatosa

  • Granulomatous Cheilitis
Ichthyosis

  • Ichthyoses

  • Non-Syndromic Ichthyosis

  • Congenital Ichthyosis
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Persistent Fetal Circulation Syndrome

  • Persistent Fetal Circulation

  • Fetal Circulation

  • Persistent Pulmonary Hypertension Of The Newborn

  • Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins

  • Persistent Foetal Circulation

  • Persistent Foetal Circulation Syndrome

  • Pfc - [Persistent Fetal Circulation] Syndrome

  • Pphn - [Persistent Pulmonary Hypertension Of The Newborn]

  • Newborn Pulmonary Hypertension

  • Primary Pulmonary Hypertension Of Newborn
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16240 Slc27a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13144 SLC27A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27156 Slc27a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SLC27A1 VGNC VGNC:77438
Mus musculus SLC27A1 MGD MGI:1347098
Felis catus SLC27A1 VGNC VGNC:65288
Canis familiaris SLC27A1 VGNC VGNC:46329
Bos taurus SLC27A1 VGNC VGNC:34785
Rattus norvegicus SLC27A1 RGD RGD:620927