2. Gene
  3. Mir143 - microRNA 143 Gene

Mir143 - microRNA 143 Gene

  • Gene
  • Agent
  • Ortholog
Mus musculus

Also known as Mirn143; mir-143; mmu-mir-143

Gene ID: 387161 | Gene type: ncRNA

About Mir143

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within aorta smooth muscle tissue morphogenesis IGI
IGI: Inferred from genetic interaction
19816508 MGI
acts upstream of or within cardiac vascular smooth muscle cell differentiation IGI
IGI: Inferred from genetic interaction
19816508 MGI
acts upstream of or within cellular response to estrogen stimulus IDA
IDA: Inferred from direct assay
18791161 MGI
acts upstream of or within cellular response to mechanical stimulus IDA
IDA: Inferred from direct assay
25959411 MGI
acts upstream of or within cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
19188425 MGI
acts upstream of or within embryo implantation IDA
IDA: Inferred from direct assay
18556655 MGI
acts upstream of or within negative effect gene expression IGI
IGI: Inferred from genetic interaction
29925839 MGI
acts upstream of or within positive effect hematopoietic stem cell proliferation IGI
IGI: Inferred from genetic interaction
29925839 MGI
acts upstream of or within miRNA-mediated gene silencing by inhibition of translation IDA
IDA: Inferred from direct assay
21441927 MGI
acts upstream of or within negative regulation of insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
21441927 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
21441927 MGI
acts upstream of or within positive regulation of adipose tissue development IDA
IDA: Inferred from direct assay
19188425 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19188425 MGI
acts upstream of or within regulation of glucose metabolic process IDA
IDA: Inferred from direct assay
21441927 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
29925839 MGI
Cellular Component GO Annotation Evidence Reference Source
located in synapse IDA
IDA: Inferred from direct assay
22897173 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-R00278 hsa-miR-143-3p mimic 94.90% Unkown
HY-R02677A mmu-miR-143-5p agomir 97.77% Unkown
HY-R00278A hsa-miR-143-3p agomir 99.36% Unkown
HY-RI00278 hsa-miR-143-3p inhibitor 95.10% Unkown
HY-RI00278A hsa-miR-143-3p antagomir 99.04% Unkown
HY-RI02677 mmu-miR-143-5p inhibitor 95.57% Unkown
HY-R02677 mmu-miR-143-5p mimic / Unkown
HY-R04234 rno-miR-143-3p mimic / Unkown
HY-R04234A rno-miR-143-3p agomir / Unkown
HY-RI02677A mmu-miR-143-5p antagomir / Unkown
HY-RI04234 rno-miR-143-3p inhibitor / Unkown
HY-RI04234A rno-miR-143-3p antagomir / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir143 NCBI NCBI:406935