2. Gene
  3. Mir186 - microRNA 186 Gene

Mir186 - microRNA 186 Gene

  • Gene
  • Agent
  • Ortholog
Mus musculus

Also known as Mirn186; mir-186; mmu-mir-186

Gene ID: 387181 | Gene type: ncRNA

About Mir186

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables mRNA 3'-UTR binding IMP
IMP: Inferred from mutant phenotype
26710318 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within miRNA-mediated gene silencing by inhibition of translation IDA
IDA: Inferred from direct assay
32109384 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
26710318 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (20)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RI04604A mmu-miR-186-5p antagomir 95.12% Unkown
HY-R00348 hsa-miR-186-5p mimic 98.36% Unkown
HY-RI00348 hsa-miR-186-5p inhibitor 96.52% Unkown
HY-R00347 hsa-miR-186-3p mimic / Unkown
HY-R00347A hsa-miR-186-3p agomir / Unkown
HY-R00348A hsa-miR-186-5p agomir / Unkown
HY-R02710 mmu-miR-186-3p mimic / Unkown
HY-R02710A mmu-miR-186-3p agomir / Unkown
HY-R04259 rno-miR-186-3p mimic / Unkown
HY-R04259A rno-miR-186-3p agomir / Unkown
HY-RI00347 hsa-miR-186-3p inhibitor / Unkown
HY-RI00347A hsa-miR-186-3p antagomir / Unkown
HY-RI00348A hsa-miR-186-5p antagomir / Unkown
HY-RI02710 mmu-miR-186-3p inhibitor / Unkown
HY-RI02710A mmu-miR-186-3p antagomir / Unkown
HY-RI04259 rno-miR-186-3p inhibitor / Unkown
HY-RI04259A rno-miR-186-3p antagomir / Unkown
HY-R04604 mmu-miR-186-5p mimic / Unkown
HY-R04604A mmu-miR-186-5p agomir / Unkown
HY-RI04604 mmu-miR-186-5p inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir186 NCBI NCBI:406962