FSIP2 - fibrous sheath interacting protein 2 Gene

Also Known as SPGF34

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 401024

About FSIP2

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:185,737,134-185,833,290 (from NCBI)

This gene has 5 transcripts (splice variants), 121 orthologues and is associated with 2 phenotypes. Biased expression in testis (RPKM 4.0), stomach (RPKM 1.4) and 2 other tissues.

Summary

This gene encodes a protein associated with the sperm fibrous sheath. Genes encoding most of the fibrous-sheath associated proteins genes are transcribed only during the postmeiotic period of spermatogenesis. The protein encoded by this gene is specific to spermatogenic cells. Copy number variation in this gene may be associated with testicular germ cell tumors. Pseudogenes associated with this gene are reported on chromosomes 2 and X. [provided by RefSeq, Aug 2016]

FSIP2 Products (1)

mRNA	Protein	Name
NM_173651.4	NP_775922.3	fibrous sheath-interacting protein 2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within positive effect flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	30745215	GOA
acts upstream of or within positive effect protein localization to cilium	IMP IMP: Inferred from mutant phenotype	30137358	GOA
involved in protein localization to cilium	IMP IMP: Inferred from mutant phenotype	30745215	GOA
acts upstream of or within positive effect sperm axoneme assembly	IMP IMP: Inferred from mutant phenotype	30137358	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in sperm end piece	IDA IDA: Inferred from direct assay	30745215	GOA
located in sperm head-tail coupling apparatus	IDA IDA: Inferred from direct assay	30745215	GOA
located in sperm midpiece	IDA IDA: Inferred from direct assay	30745215	GOA
located in sperm principal piece	IMP IMP: Inferred from mutant phenotype	30745215	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
fibrous sheath-interacting protein 2

Related Diseases

Diseases	Alias
Spermatogenic Failure 34	SPGF34
Non-Syndromic Male Infertility Due To Sperm Motility Disorder	Non-Syndromic Male Infertility Due Asthenozoospermia
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Infertility
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05126	FSIP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FSIP2	RGD	RGD:1593013
Bos taurus	FSIP2	VGNC	VGNC:56115
Mus musculus	FSIP2	MGD	MGI:2664111
Canis familiaris	FSIP2	VGNC	VGNC:53095
Others	FSIP2	NCBI