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LMOD2 - leiomodin 2 Gene

Also Known as CLMOD; CMD2G; C-LMOD

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 442721

About LMOD2

Cytogenetic location: 7q31.32 Genomic coordinates (GRCh38): 7:123,655,866-123,664,290 (from NCBI)

This gene has 2 transcripts (splice variants), 240 orthologues and 6 paralogues. Restricted expression toward heart (RPKM 307.4).

Summary

Enables actin monomer binding activity and tropomyosin binding activity. Involved in actin nucleation; positive regulation of actin filament polymerization; and sarcomere organization. Located in actin filament and sarcomere. Colocalizes with M band. [provided by Alliance of Genome Resources, Apr 2022]

LMOD2 Products (1)

mRNA	Protein	Name
NM_207163.3	NP_997046.1	leiomodin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin binding	IDA IDA: Inferred from direct assay	18403713	GOA
enables actin monomer binding	IMP IMP: Inferred from mutant phenotype	25250574	GOA
enables tropomyosin binding	IMP IMP: Inferred from mutant phenotype	25250574	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin nucleation	IDA IDA: Inferred from direct assay	20685966	GOA
involved in actin nucleation	IMP IMP: Inferred from mutant phenotype	25250574	GOA
involved in positive regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	26370058	GOA
involved in sarcomere organization	IMP IMP: Inferred from mutant phenotype	18403713	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with M band	IDA IDA: Inferred from direct assay	18403713	GOA
located in actin filament	IDA IDA: Inferred from direct assay	26370058	GOA
located in myofibril	IDA IDA: Inferred from direct assay	20685966	GOA
located in sarcomere	IDA IDA: Inferred from direct assay	18403713	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LMOD2 Protein Structure

Tropomodulin

0
100
200
300
400
500
547 a.a.

Protein Preferred Names	Protein Names
leiomodin-2	cardiac leiomodin

Related Diseases

Diseases	Alias
Cardiomyopathy, Dilated, 2g	CMD2G Dilated Cardiomyopathy 2g
Familial Isolated Dilated Cardiomyopathy	Familial Or Idiopathic Dilated Cardiomyopathy
Nemaline Myopathy 10	NEM10 Myopathy, Nemaline, Type 10
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1	Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome Berdon Syndrome MMIHS Megacystis Microcolon Intestinal Hypoperistalsis Syndrome Megacystis, Microcolon, Hypoperistalsis Syndrome Visceral Myopathy Mmih Syndrome Megacystis-Microcolon-Intestinal Hypoperistalsis-Hydronephrosis Syndrome MMIHS1 Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome, Mmih Mmhs
Autoimmune Epilepsy
Congenital Structural Myopathy
Hemoglobin H Disease	HBH Hemoglobin H Disease, Nondeletional Hemoglobin H Disease, Deletional Alpha-Thalassemia Intermedia Haemoglobin H Disease Alpha-Thalassemia, Hemoglobin H Type Hemoglobin H Disease, Deletional And Nondeletional Alpha Thalassemia, Haemoglobin H Type Alpha Thalassemia, Hemoglobin H Type Haemoglobin H Disease, Deletional Hbh Disease Alpha-Thalassemia Hemoglobin H Type Hemoglobin H Disease Deletional Hemoglobin H Disease Non-Deletional Alpha-Thalassemia Alpha - /- - Or Mutational Forms Of Alpha-Thalassaemia Alpha Thalassaemia Intermedia
Congenital Fiber-Type Disproportion	Congenital Fiber Type Disproportion Cftdm Congenital Myopathy With Fiber Type Disproportion Cftd Congenital Fiber-Type Disproportion Myopathy Fiber-Type Disproportion Myopathy, Congenital Myopathy, Congenital With Fiber-Type Disproportion
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07723	LMOD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LMOD2	VGNC	VGNC:81634
Felis catus	LMOD2	VGNC	VGNC:80611
Canis familiaris	LMOD2	VGNC	VGNC:54785
Mus musculus	LMOD2	MGD	MGI:2135672
Bos taurus	LMOD2	VGNC	VGNC:30939
Rattus norvegicus	LMOD2	RGD	RGD:1592092
Others	LMOD2	NCBI