MT1G - metallothionein 1G Gene

Also Known as MT1; MT1K

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4495

About MT1G

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,666,730-56,668,065 (from NCBI)

This gene has 4 transcripts (splice variants), 218 orthologues and 11 paralogues. Biased expression in kidney (RPKM 963.2), thyroid (RPKM 736.8) and 7 other tissues.

Summary

Enables zinc ion binding activity. Involved in cellular response to metal ion; cellular response to vascular endothelial growth factor stimulus; and negative regulation of growth. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MT1G Products (2)

mRNA Protein Name
NM_001301267.2 NP_001288196.1 metallothionein-1G isoform 2
NM_005950.3 NP_005941.1 metallothionein-1G isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12646258 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
8119276 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to cadmium ion IEP
IEP: Inferred from expression pattern
3403543 GOA
involved in cellular response to copper ion IEP
IEP: Inferred from expression pattern
3403543 GOA
involved in cellular response to vascular endothelial growth factor stimulus IEP
IEP: Inferred from expression pattern
15735762 GOA
involved in cellular response to zinc ion IDA
IDA: Inferred from direct assay
7559655 GOA
involved in cellular response to zinc ion IEP
IEP: Inferred from expression pattern
3403543 GOA
involved in negative regulation of growth IDA
IDA: Inferred from direct assay
18332874 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
3403543 GOA
located in nucleus IDA
IDA: Inferred from direct assay
7559655 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MT1G Protein Structure

Metallothio

Metallothio: Metallothionein (1 - 62)

  • 0
  • 62 a.a.
Protein Preferred Names Protein Names

metallothionein-1G

  • MT-1G

MT1G Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MT1G P13640 SPINK7 Homo sapiens P58062
Y2H
12970870
Intra
MT1G P13640 SPINK7 Homo sapiens P58062
Y2H
12646258
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Deficiency Anemia

  • Anemia

  • Deficiency Anemias

  • Anaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08739 MT1G Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MT1G MGD MGI:97171