NPAT - nuclear protein, coactivator of histone transcription Gene

Homo sapiens

Also known as E14; p220; E14/NPAT

Gene ID: 4863 | Gene type: protein coding

About NPAT

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:108,157,215-108,222,638 (from NCBI)

This gene has 6 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in lymph node (RPKM 6.0), spleen (RPKM 3.9) and 25 other tissues.

Summary

Enables protein C-terminus binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in positive regulation of transcription by RNA polymerase II and regulation of transcription involved in G1/S transition of mitotic cell cycle. Located in Cajal body; Gemini of coiled bodies; and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NPAT Products(2)

mRNA	Protein	Name
NM_001321307.1	NP_001308236.1	protein NPAT isoform 1
NM_002519.3	NP_002510.2	protein NPAT isoform 2

Protein Preferred Names

Protein Names

protein NPAT

nuclear protein of the ATM locus

Related Diseases

Diseases

Alias

Ataxia-Telangiectasia

Ataxia Telangiectasia	Louis-Bar Syndrome
AT	At1
Ataxia-Telangiectasia Syndrome	Ataxia - Telangiectasia Variant
Boder-Sedgwick Syndrome	Louis Bar Syndrome
Cerebello-Oculocutaneous Telangiectasia	Immunodeficiency With Ataxia Telangiectasia
A-T	Ataxia Telangiectasia Syndrome
Atm	Telangiectasia, Cerebello-Oculocutaneous
Ataxia-Telangiectasia Variant

Nasal Cavity Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Nasal Cavity

Squamous Cell Carcinoma Of The Nasal Cavity

Alpha Thalassemia-Intellectual Disability Syndrome Type 1

Alpha Thalassemia-Intellectual Disability Syndrome, Deletion Type	Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16
Atr Syndrome Linked To Chromosome 16	Atr Syndrome, Deletion Type
Atr-16 Syndrome	Alpha Thalassemia-Retardation Syndrome
Alpha-Thalassemia/Mental Retardation Syndrome, Deletion-Type	Alpha-Thalassemia/Mental Retardation Syndrome, Type 1
Alpha-Thalassemia Mental Retardation Syndrome, Deletion-Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09472	NPAT Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NPAT	VGNC	VGNC:50638
Mus musculus	NPAT	MGD	MGI:107605
Felis catus	NPAT	VGNC	VGNC:68527
Bos taurus	NPAT	VGNC	VGNC:50617
Rattus norvegicus	NPAT	RGD	RGD:1311947
Macaca mulatta	NPAT	VGNC	VGNC:75379