ANO7 - anoctamin 7 Gene

Also Known as NGEP; DTMPP; IPCA5; D-TMPP; IPCA-5; PCANAP5; TMEM16G; PCANAP5L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 50636

About ANO7

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,188,677-241,240,308 (from NCBI)

This gene has 10 transcripts (splice variants), 145 orthologues and 10 paralogues. Biased expression in prostate (RPKM 34.0), stomach (RPKM 8.3) and 3 other tissues.

Summary

This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate Cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2011]

ANO7 Products (2)

mRNA Protein Name
NM_001001666.4 NP_001001666.2 anoctamin-7 isoform 2
NM_001370694.2 NP_001357623.1 anoctamin-7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables intracellularly calcium-gated chloride channel activity IDA
IDA: Inferred from direct assay
21984732 GOA
enables intracellularly calcium-gated chloride channel activity IDA
IDA: Inferred from direct assay
22946059 GOA
Biological Process GO Annotation Evidence References Source
involved in chloride transmembrane transport IDA
IDA: Inferred from direct assay
22946059 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
22075693 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
14981236 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANO7 Protein Structure

Anoctamin

Anoctamin: Calcium-activated chloride channel (335 - 888)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 933 a.a.
Protein Preferred Names Protein Names

anoctamin-7

  • Dresden-transmembrane protein of the prostate

Related Diseases

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Spinocerebellar Ataxia, Autosomal Recessive 10

  • SCAR10

  • Autosomal Recessive Spinocerebellar Ataxia 10

  • Adult-Onset Autosomal Recessive Cerebellar Ataxia

  • Autosomal Recessive Spinocerebellar Ataxia Type 10

  • Spinocerebellar Ataxia, Autosomal Recessive, 10

  • Ataxia, Spinocerebellar, Autosomal Recessive, Type 10
Miyoshi Muscular Dystrophy 3

  • MMD3

  • Miyoshi Myopathy 3

  • Distal Anoctaminopathy

  • Miyoshi Muscular Dystrophy Type 3

  • Dystrophy, Muscular, Miyoshi, Type 3
Gnathodiaphyseal Dysplasia

  • GDD

  • Osteogenesis Imperfecta With Unusual Skeletal Lesions

  • Gnathodiaphyseal Sclerosis

  • Osteogenesis Imperfecta, Levin Type

  • Levin Syndrome 2

  • Dysplasia, Gnathodiaphyseal
Scott Syndrome

  • SCTS

  • Bdplt7

  • Prothrombin Consumption Deficiency

  • Bleeding Abnormality Due To Deficiency Of Platelet Binding Of Factor X

  • Bleeding Disorder, Platelet-Type, 7

  • Prothrombin Conversion Defect, Familial

  • Prothrombin Consumption Inhibitor, Familial

  • Bleeding Abnormality Due To Deficiency Of Platelet Biding Of Factor X

  • Familial Prothrombin Consumption Inhibitor

  • Familial Prothrombin Conversion Defect

  • Platelet-Type Bleeding Disorder 7

  • Platelet Factor X Receptor Deficiency

  • Bleeding Disorder Platelet-Type 7

  • Prothrombin Consumption Inhibitor Familial

  • Prothrombin Conversion Defect Familial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00747 ANO7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ANO7 MGD MGI:3052714
Canis familiaris ANO7 VGNC VGNC:59073
Felis catus ANO7 VGNC VGNC:59832
Rattus norvegicus ANO7 RGD RGD:1302987
Macaca mulatta ANO7 VGNC VGNC:69933
Others ANO7 NCBI