Ptpro - protein tyrosine phosphatase, receptor type, O Gene

Also Known as GLEPP1; RPTP-BK

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 50677

Summary

Enables protein tyrosine Phosphatase activity. Involved in negative regulation of glomerular filtration. Predicted to be located in apical plasma membrane; dendritic spine; and lateral plasma membrane. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and plasma membrane. Predicted to be integral component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 6. Orthologous to human PTPRO (protein tyrosine Phosphatase receptor type O). [provided by Alliance of Genome Resources, Apr 2022]

Ptpro Products (1)

mRNA Protein Name
NM_017336.2 NP_059032.1 receptor-type tyrosine-protein phosphatase O precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
9032477 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of glomerular filtration IMP
IMP: Inferred from mutant phenotype
19403647 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase O

  • Glomerular epithelial protein 1

  • receptor-type protein tyrosine phosphatase D30

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N1966 (E)-Osmundacetone 99.81% Unkown
HY-183573 PTPRO-IN-1 Inhibitor / Unkown
HY-RS11446 PTPRO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11451 PTPRU Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptpro NCBI NCBI:5800