PBX3 - PBX homeobox 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5090

About PBX3

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:125,747,373-125,967,377 (from NCBI)

This gene has 14 transcripts (splice variants), 104 orthologues and 12 paralogues. Ubiquitous expression in adrenal (RPKM 28.9), ovary (RPKM 26.1) and 25 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in animal organ development; neuron development; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including adult locomotory behavior; dorsal spinal cord development; and regulation of respiratory gaseous exchange by nervous system process. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

PBX3 Products (4)

mRNA Protein Name
NM_001134778.2 NP_001128250.1 pre-B-cell leukemia transcription factor 3 isoform 2
NM_001330782.2 NP_001317711.1 pre-B-cell leukemia transcription factor 3 isoform 3
NM_001411009.1 NP_001397938.1 pre-B-cell leukemia transcription factor 3 isoform 4
NM_006195.6 NP_006186.1 pre-B-cell leukemia transcription factor 3 isoform 1

PBX3 Protein Structure

PBC

PBC: PBC domain (42 - 234)

Homeobox

Homeobox: Homeobox domain (236 - 295)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 434 a.a.
Protein Preferred Names Protein Names

pre-B-cell leukemia transcription factor 3

  • homeobox protein PBX3

Related Diseases

Diseases Alias
Myoepithelioma

  • Benign Myoepithelioma

  • Myoepithelial Adenoma

  • Myoepithelial Neoplasm

  • Malignant Myoepithelioma
Bone Epithelioid Hemangioma

  • Bone Hemangioma

  • Hemangioma Of Bone

  • Osseous Epithelioid Hemangioma

  • Osseous Hemangioma
Chondrosarcoma, Extraskeletal Myxoid

  • Extraskeletal Myxoid Chondrosarcoma

  • Emc

  • Myxoid Extraosseous Chondrosarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P3245A HXR9 hydrochloride 99.48% Unkown
HY-P3245 HXR9 Inducer / Unkown
HY-RS10108 PBX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22270 Pbx3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28793 Pbx3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PBX3 RGD RGD:1307198
Canis familiaris PBX3 VGNC VGNC:44288
Mus musculus PBX3 MGD MGI:97496
Bos taurus PBX3 VGNC VGNC:32609
Macaca mulatta PBX3 VGNC VGNC:82202
Felis catus PBX3 VGNC VGNC:68708
Others PBX3 NCBI