ZDHHC9 - zinc finger DHHC-type palmitoyltransferase 9 Gene

Also Known as CGI89; DHHC9; MMSA1; MRXSR; MRXSZ; ZNF379; ZNF380; CXorf11; ZDHHC10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51114

About ZDHHC9

Cytogenetic location: Xq26.1 Genomic coordinates (GRCh38): X:129,803,288-129,843,886 (from NCBI)

This gene has 5 transcripts (splice variants), 213 orthologues, 17 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 17.9), kidney (RPKM 10.5) and 25 other tissues.

Summary

This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase. This protein specifically palmitoylates HRAS and NRAS. Mutations in this gene are associated with X-linked cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, May 2010]

ZDHHC9 Products (2)

mRNA	Protein	Name
NM_001008222.3	NP_001008223.1	palmitoyltransferase ZDHHC9
NM_016032.4	NP_057116.2	palmitoyltransferase ZDHHC9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Ras palmitoyltransferase activity	IDA IDA: Inferred from direct assay	16000296	GOA
enables palmitoyltransferase activity	IDA IDA: Inferred from direct assay	23034182	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25910212	GOA
enables protein-cysteine S-palmitoyltransferase activity	IDA IDA: Inferred from direct assay	37802025	GOA
enables protein-cysteine S-palmitoyltransferase activity	IMP IMP: Inferred from mutant phenotype	34599882	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in peptidyl-L-cysteine S-palmitoylation	IDA IDA: Inferred from direct assay	16000296	GOA
involved in peptidyl-L-cysteine S-palmitoylation	IMP IMP: Inferred from mutant phenotype	27481942	GOA
involved in positive regulation by host of viral process	IDA IDA: Inferred from direct assay	34599882	GOA
involved in positive regulation by host of viral process	IMP IMP: Inferred from mutant phenotype	34599882	GOA
involved in positive regulation of cGAS/STING signaling pathway	IDA IDA: Inferred from direct assay	37802025	GOA
involved in positive regulation of pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	38530158	GOA
involved in protein palmitoylation	IDA IDA: Inferred from direct assay	23034182	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	16647879	GOA
located in Golgi membrane	IDA IDA: Inferred from direct assay	16000296	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16000296	GOA
part of palmitoyltransferase complex	IDA IDA: Inferred from direct assay	16000296	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZDHHC9 Protein Structure

DHHC

0
100
200
300
364 a.a.

Protein Preferred Names	Protein Names
palmitoyltransferase ZDHHC9	Asp-His-His-Cys domain containing protein 9

ZDHHC9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZDHHC9	Q9Y397	CREB3	Homo sapiens	O43889-2	Validated Y2H	25910212
Intra	ZDHHC9	Q9Y397	CREB3	Homo sapiens	O43889-2	Y2H Array	25910212
Intra	ZDHHC9	Q9Y397	CREB3	Homo sapiens	O43889-2	Y2H Bait-Prey Pool	25910212

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, X-Linked, Syndromic, Raymond Type	MRXSR Syndromic X-Linked Intellectual Disability Raymond Type Mental Retardation, X-Linked, Syndromic, Raymond Type Mental Retardation, X-Linked Syndromic, Raymond Type Intellectual Developmental Disorder, X-Linked Syndromic, Raymond Type X-Linked Syndromic Intellectual Developmental Disorder Raymond Type
Intellectual Developmental Disorder, X-Linked, Syndromic, Lujan-Fryns Type	Lujan-Fryns Syndrome X-Linked Intellectual Disability With Marfanoid Habitus MRXSLF Mental Retardation, X-Linked, With Marfanoid Habitus, 1
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations	Star Syndrome Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome Syndactyly With Renal And Anogenital Malformations STAR Syndactyly, Telecanthus, Anogenital And Renal Malformations Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations
Benign Epilepsy With Centrotemporal Spikes	Rolandic Epilepsy Benign Rolandic Epilepsy Epilepsy, Rolandic Bcects Benign Childhood Epilepsy With Centrotemporal Spike Sylvan Seizures Becrs Bects Bre Benign Epilepsy Of Childhood With Centrotemporal Spikes Benign Familial Epilepsy Of Childhood With Rolandic Spikes Centrotemporal Epilepsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-155938	Cyano-myracrylamide	Inhibitor	98.13%	Phase 3

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16024	ZDHHC9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ZDHHC9	VGNC	VGNC:37146
Felis catus	ZDHHC9	VGNC	VGNC:67220
Canis familiaris	ZDHHC9	VGNC	VGNC:48595
Mus musculus	ZDHHC9	MGD	MGI:2444393
Macaca mulatta	ZDHHC9	VGNC	VGNC:79147
Rattus norvegicus	ZDHHC9	RGD	RGD:1561389
Others	ZDHHC9	NCBI