SHISA5 - shisa family member 5 Gene

Also Known as SCOTIN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51246

About SHISA5

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,467,876-48,504,810 (from NCBI)

This gene has 19 transcripts (splice variants), 121 orthologues and 2 paralogues. Ubiquitous expression in placenta (RPKM 49.3), spleen (RPKM 32.3) and 25 other tissues.

Summary

This gene encodes a member of the shisa family. The encoded protein is localized to the endoplasmic reticulum, and together with p53 induces Apoptosis in a caspase-dependent manner. Alternative splicing results in multiple transcript variants. Related pseudogenes of this gene are found on chromosome X. [provided by RefSeq, Apr 2016]

SHISA5 Products (7)

mRNA	Protein	Name
NM_001272065.3	NP_001258994.1	protein shisa-5 isoform b precursor
NM_001272066.2	NP_001258995.1	protein shisa-5 isoform c
NM_001272067.2	NP_001258996.1	protein shisa-5 isoform c
NM_001272068.2	NP_001258997.1	protein shisa-5 isoform c
NM_001272082.4	NP_001259011.1	protein shisa-5 isoform d
NM_001272083.4	NP_001259012.1	protein shisa-5 isoform e
NM_016479.6	NP_057563.3	protein shisa-5 isoform a precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables WW domain binding	IPI IPI: Inferred from physical interaction	15064722	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15064722	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHISA5 Protein Structure

Shisa

0
100
200
240 a.a.

Protein Preferred Names	Protein Names
protein shisa-5	putative NF-kappa-B-activating protein 120

SHISA5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	SHISA5	Q8N114	Pdcd6	Mus musculus	P12815	Far-WB	17889823
Cross	SHISA5	Q8N114	Pdcd6	Mus musculus	P12815	Pull Down	17889823
Cross	SHISA5	Q8N114	Pdcd6	Mus musculus	P12815	Anti Tag CoIP	17889823
Intra	SHISA5	Q8N114	WWOX	Homo sapiens	Q9NZC7	Far-WB	15064722

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Bn2 Diffuse Large B-Cell Lymphoma	Bn2 Dlbcl Doid:0081064
Microcephaly 6, Primary, Autosomal Recessive	MCPH6 Primary Autosomal Recessive Microcephaly 6 Microcephaly, Primary Autosomal Recessive, 6 Microcephaly, Type 6, Primary, Autosomal Recessive
Fanconi Anemia, Complementation Group C	Fanconi Anemia Complementation Group C FANCC Facc Fac Fa3 Fanconi Pancytopenia Type 3 Fanconi Pancytopenia, Type 3 Faces Syndrome Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies Friedman-Goodman Syndrome Abnormality Of The Face

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12868	SHISA5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SHISA5	VGNC	VGNC:84082
Mus musculus	SHISA5	MGD	MGI:1915044
Canis familiaris	SHISA5	VGNC	VGNC:108258
Bos taurus	SHISA5	VGNC	VGNC:34601
Rattus norvegicus	SHISA5	RGD	RGD:1359661
Felis catus	SHISA5	VGNC	VGNC:80715