2. Gene
  3. SHISA5 - shisa family member 5 Gene

SHISA5 - shisa family member 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SCOTIN

Gene ID: 51246 | Gene type: protein coding

About SHISA5

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,467,876-48,504,810 (from NCBI)

This gene has 19 transcripts (splice variants), 121 orthologues and 2 paralogues. Ubiquitous expression in placenta (RPKM 49.3), spleen (RPKM 32.3) and 25 other tissues.

Summary

This gene encodes a member of the shisa family. The encoded protein is localized to the endoplasmic reticulum, and together with p53 induces Apoptosis in a caspase-dependent manner. Alternative splicing results in multiple transcript variants. Related pseudogenes of this gene are found on chromosome X. [provided by RefSeq, Apr 2016]

SHISA5 Products(7)

mRNA Protein Name
NM_001272065.3 NP_001258994.1 protein shisa-5 isoform b precursor
NM_001272066.2 NP_001258995.1 protein shisa-5 isoform c
NM_001272067.2 NP_001258996.1 protein shisa-5 isoform c
NM_001272068.2 NP_001258997.1 protein shisa-5 isoform c
NM_001272082.4 NP_001259011.1 protein shisa-5 isoform d
NM_001272083.4 NP_001259012.1 protein shisa-5 isoform e
NM_016479.6 NP_057563.3 protein shisa-5 isoform a precursor

SHISA5 Protein Structure

Shisa

Shisa: Wnt and FGF inhibitory regulator (27 - 209)

  • 0
  • 100
  • 200
  • 240 a.a.
Protein Preferred Names Protein Names

protein shisa-5

putative NF-kappa-B-activating protein 120

Related Diseases

Diseases Alias
Bn2 Diffuse Large B-Cell Lymphoma

Bn2 Dlbcl

Doid:0081064
Microcephaly 6, Primary, Autosomal Recessive

MCPH6

Primary Autosomal Recessive Microcephaly 6

Microcephaly, Primary Autosomal Recessive, 6

Microcephaly, Type 6, Primary, Autosomal Recessive
Fanconi Anemia, Complementation Group C

Fanconi Anemia Complementation Group C

FANCC

Facc

Fac

Fa3

Fanconi Pancytopenia Type 3

Fanconi Pancytopenia, Type 3

Faces Syndrome

Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies

Friedman-Goodman Syndrome

Abnormality Of The Face
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12868 SHISA5 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SHISA5 VGNC VGNC:84082
Mus musculus SHISA5 MGD MGI:1915044
Canis familiaris SHISA5 VGNC VGNC:108258
Bos taurus SHISA5 VGNC VGNC:34601
Rattus norvegicus SHISA5 RGD RGD:1359661
Felis catus SHISA5 VGNC VGNC:80715