SCARA3 - scavenger receptor class A member 3 Gene

Also Known as CSR; APC7; CSR1; MSLR1; MSRL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51435

About SCARA3

Cytogenetic location: 8p21.1 Genomic coordinates (GRCh38): 8:27,633,463-27,734,141 (from NCBI)

This gene has 2 transcripts (splice variants), 210 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 16.5), brain (RPKM 14.0) and 23 other tissues.

Summary

This gene encodes a macrophage scavenger receptor-like protein. This protein has been shown to deplete Reactive Oxygen Species, and thus play an important role in protecting cells from oxidative stress. The expression of this gene is induced by oxidative stress. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

SCARA3 Products (2)

mRNA Protein Name
NM_016240.3 NP_057324.2 scavenger receptor class A member 3 isoform 1
NM_182826.2 NP_878185.1 scavenger receptor class A member 3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
NOT involved in toll-like receptor 3 signaling pathway IMP
IMP: Inferred from mutant phenotype
25204797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCARA3 Protein Structure

Collagen

Collagen: Collagen triple helix repeat (20 copies) (456 - 512)

Collagen

Collagen: Collagen triple helix repeat (20 copies) (499 - 557)

Collagen

Collagen: Collagen triple helix repeat (20 copies) (544 - 602)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 606 a.a.
Protein Preferred Names Protein Names

scavenger receptor class A member 3

  • cellular stress response gene protein

SCARA3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SCARA3 Q6AZY7 COLEC12 Homo sapiens Q5KU26
Anti Tag CoIP
33961781
Intra
SCARA3 Q6AZY7 SYNGR2 Homo sapiens O43760
Validated Y2H
25416956
Intra
SCARA3 Q6AZY7 SYNGR2 Homo sapiens O43760
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hand, Foot And Mouth Disease

  • Vesicular Stomatitis And Exanthem
Coffin-Siris Syndrome 3

  • CSS3

  • Mrd15

  • Mental Retardation, Autosomal Dominant 15

  • Autosomal Dominant Mental Retardation 15

  • Coffin-Siris Syndrome, Type 3
Flinders Island Spotted Fever

  • Fisf

  • Thai Tick Typhus
Queensland Tick Typhus

  • Australian Tick Typhus

  • North Queensland Tick Typhus

  • Rickettsia Australis Spotted Fever
Mouth Disease

  • Mouth Diseases

  • Mouth Disorders
Osteogenesis Imperfecta, Type Ii

  • Vrolik Type Of Osteogenesis Imperfecta

  • Osteogenesis Imperfecta Type 2

  • OI2

  • Oi, Type Ii

  • Osteogenesis Imperfecta Congenita

  • Oic

  • Osteogenesis Imperfecta Type Ii

  • Lethal Osteogenesis Imperfecta

  • Oi Type 2

  • Osteogenesis Imperfecta Congenita Perinatal Lethal Form

  • Osteogenesis Imperfecta Congenita, Perinatal Lethal Form

  • Perinatal Lethal Osteogenesis Imperfecta Congenita

  • Perinatally Lethal Oi

  • Osteogenesis Imperfecta 2

  • Oi-Ii

  • Oi-Iia

  • Oi Type Iia

  • Osteogenesis Imperfecta Type Iia

  • Osteogenesis Imperfecta Type Ii Autosomal Dominant

  • Oi Type Ii

  • Osteogenesis Imperfecta, Dominant Perinatal Lethal
Osteogenesis Imperfecta, Type I

  • Osteogenesis Imperfecta Type I

  • OI1

  • Oi, Type I

  • Osteogenesis Imperfecta Tarda

  • Osteogenesis Imperfecta With Blue Sclerae

  • Osteogenesis Imperfecta Type 1

  • Adair-Dighton Syndrome

  • Mild Osteogenesis Imperfecta

  • Non-Deforming Osteogenesis Imperfecta

  • Oi Type 1

  • Van Der Hoeve Syndrome

  • Classic Non-Deforming Oi With Blue Sclerae

  • Osteogenesis Imperfecta 1

  • Oi-I

  • Osteopenic Non-Fracture Syndrome

  • Osteogenesis Imperfecta, Mild

  • Osteogenesis Imperfecta

  • Lobstein'S Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12486 SCARA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21190 Scara3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27706 Scara3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SCARA3 VGNC VGNC:81561
Canis familiaris SCARA3 VGNC VGNC:45896
Rattus norvegicus SCARA3 RGD RGD:1309269
Felis catus SCARA3 VGNC VGNC:80000
Bos taurus SCARA3 VGNC VGNC:34322
Mus musculus SCARA3 MGD MGI:2444418
Others SCARA3 NCBI