JKAMP - JNK1/MAPK8 associated membrane protein Gene

Also Known as JAMP; CDA06; HSPC213; HSPC327; C14orf100; C24orf100

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51528

About JKAMP

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:59,484,517-59,505,410 (from NCBI)

This gene has 14 transcripts (splice variants) and 219 orthologues. Ubiquitous expression in testis (RPKM 16.2), adrenal (RPKM 14.0) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Involved in ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

JKAMP Products (6)

mRNA	Protein	Name
NM_001098625.3	NP_001092095.1	JNK1/MAPK8-associated membrane protein isoform 2
NM_001284201.2	NP_001271130.1	JNK1/MAPK8-associated membrane protein isoform 3
NM_001284202.2	NP_001271131.1	JNK1/MAPK8-associated membrane protein isoform 4
NM_001284203.2	NP_001271132.1	JNK1/MAPK8-associated membrane protein isoform 5
NM_001284204.2	NP_001271133.1	JNK1/MAPK8-associated membrane protein isoform 6
NM_016475.5	NP_057559.2	JNK1/MAPK8-associated membrane protein isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19269966	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ERAD pathway	IDA IDA: Inferred from direct assay	19269966	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JKAMP Protein Structure

DUF766

0
100
200
311 a.a.

Protein Preferred Names	Protein Names
JNK1/MAPK8-associated membrane protein	JNK-associated membrane protein

Related Diseases

Diseases	Alias
Large Cell Medulloblastoma
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Nemaline Myopathy 5	Amish Nemaline Myopathy NEM5 Anm Nemaline Myopathy, Amish Type Nemaline Myopathy 5, Amish Type Nemaline Myopathy, Caused By Mutation In The Troponin T1 Gene Nemaline Myopathy, Type 5 Nemaline Myopathy Amish Type Tnnt1-Related Nemaline Myopathy Myopathy, Nemaline, Type 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07036	JKAMP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	JKAMP	VGNC	VGNC:42186
Rattus norvegicus	JKAMP	RGD	RGD:1308917
Felis catus	JKAMP	VGNC	VGNC:63006
Macaca mulatta	JKAMP	VGNC	VGNC:73867
Bos taurus	JKAMP	VGNC	VGNC:30375
Mus musculus	JKAMP	MGD	MGI:1915057
Others	JKAMP	NCBI