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ADAM22 - ADAM metallopeptidase domain 22 Gene

Also Known as MDC2; DEE61; EIEE61; ADAM 22

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 53616

About ADAM22

Cytogenetic location: 7q21.12 Genomic coordinates (GRCh38): 7:87,934,251-88,202,889 (from NCBI)

This gene has 14 transcripts (splice variants), 209 orthologues, 20 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 9.0), adrenal (RPKM 2.5) and 10 other tissues.

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike Other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an Integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]

ADAM22 Products (18)

mRNA	Protein	Name
NM_001324417.2	NP_001311346.1	disintegrin and metalloproteinase domain-containing protein 22 isoform 6 precursor
NM_001324418.2	NP_001311347.1	disintegrin and metalloproteinase domain-containing protein 22 isoform 7 precursor
NM_001324419.2	NP_001311348.1	disintegrin and metalloproteinase domain-containing protein 22 isoform 8 precursor
NM_001324420.2	NP_001311349.1	disintegrin and metalloproteinase domain-containing protein 22 isoform 9 precursor
NM_001324421.2	NP_001311350.1	disintegrin and metalloproteinase domain-containing protein 22 isoform 10 precursor
NM_001391975.1	NP_001378904.1	disintegrin and metalloproteinase domain-containing protein 22 isoform 11 precursor
NM_001391976.1	NP_001378905.1	disintegrin and metalloproteinase domain-containing protein 22 isoform 12 precursor
NM_001391977.1	NP_001378906.1	disintegrin and metalloproteinase domain-containing protein 22 isoform 13 precursor
NM_001391978.1	NP_001378907.1	disintegrin and metalloproteinase domain-containing protein 22 isoform 14 precursor
NM_001391979.1	NP_001378908.1	disintegrin and metalloproteinase domain-containing protein 22 isoform 15 precursor
NM_001391980.1	NP_001378909.1	disintegrin and metalloproteinase domain-containing protein 22 isoform 16 precursor
NM_001391981.1	NP_001378910.1	disintegrin and metalloproteinase domain-containing protein 22 isoform 17 precursor
NM_001391982.1	NP_001378911.1	disintegrin and metalloproteinase domain-containing protein 22 isoform 18 precursor
NM_004194.5	NP_004185.1	disintegrin and metalloproteinase domain-containing protein 22 isoform 4 precursor
NM_016351.6	NP_057435.2	disintegrin and metalloproteinase domain-containing protein 22 isoform 3 precursor
NM_021721.5	NP_068367.1	disintegrin and metalloproteinase domain-containing protein 22 isoform 5 precursor
NM_021722.6	NP_068368.2	disintegrin and metalloproteinase domain-containing protein 22 isoform 2 precursor
NM_021723.5	NP_068369.1	disintegrin and metalloproteinase domain-containing protein 22 isoform 1 preproprotein

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12589811	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	27066583	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAM22 Protein Structure

Pep_M12B_propep

Reprolysin

Disintegrin

ADAM_CR

0
200
400
600
800
906 a.a.

Protein Preferred Names	Protein Names
disintegrin and metalloproteinase domain-containing protein 22	a disintegrin and metalloproteinase domain 22

Related Diseases

Diseases	Alias
Developmental And Epileptic Encephalopathy 61	DEE61 Epileptic Encephalopathy, Early Infantile, 61 Eiee61 Developmental And Epileptic Encephalopathy, 61 Early Infantile Epileptic Encephalopathy 61 Encephalopathy, Epileptic, Early Infantile, Type 61
Limbic Encephalitis
Epilepsy, Familial Temporal Lobe, 1	ETL1 Adpeaf Adlte Epilepsy, Partial, With Auditory Features Autosomal Dominant Partial Epilepsy With Auditory Features Epilepsy, Lateral Temporal Lobe, Autosomal Dominant Familial Temporal Lobe Epilepsy 1 Partial Epilepsy With Auditory Features Autosomal Dominant Lateral Temporal Lobe Epilepsy Lateral Temporal Lobe Epilepsy Autosomal Dominant Epilepsy, Temporal Lobe, Familial, Type 1
Cardiomyopathy, Dilated, 1c, With Or Without Left Ventricular Noncompaction	Left Ventricular Noncompaction 3 Dilated Cardiomyopathy 1c CMD1C Cardiomyopathy, Hypertrophic, 24 Dilated Cardiomyopathy With Left Ventricular Noncompaction Cardiomyopathy, Dilated, 1c, With Or Without Lvnc Cmdc1 Dilated Cardiomyopathy 1c With Or Without Left Ventricular Noncompaction Cardiomyopathy, Dilated 1c, With Or Without Left Ventricular Non-Compaction Cardiomyopathy Dilated With Left Ventricular Noncompaction Cardiomyopathy, Familial Hypertrophic 24 CMH24 Left Ventricular Non-Compaction 3 LVNC3 Cardiomyopathy, Dilated 1c Familial Hypertrophic Cardiomyopathy 24 Cardiomyopathy, Dilated, 1c
Developmental And Epileptic Encephalopathy	Encephalopathy, Developmental And Epileptic
Amnestic Disorder	Amnesia Amnestic Syndrome Korsakoff'S Psychosis Or Syndrome Amnesic Syndrome Amnestic Disorder In Conditions Classified Elsewhere Korsakoff Psychosis Or Syndrome, Nonalcoholic Nonalcoholic Organic Amnesic Syndrome Organic Amnesic Syndrome
Hyperekplexia	Hereditary Hyperekplexia Kok Disease Congenital Stiff Man Syndrome Familial Startle Disease Sthe Stiff-Baby Syndrome Hereditary Hyperexplexia Startle Disease Exaggerated Startle Reaction Hyperexplexia Hereditary Startle Disease, Familial Startle Reaction, Exaggerated Stiff-Man Syndrome, Congenital Stiff-Person Syndrome, Congenital Congenital Stiff-Man Syndrome Congenital Stiff-Person Syndrome Familial Hyperekplexia Startle Syndrome Stiff Baby Syndrome Hyperekplexia, Hereditary Stiff-Person Syndrome
Early Infantile Epileptic Encephalopathy	Early Infantile Epileptic Encephalopathy With Burst-Suppression Early Infantile Epileptic Encephalopathy With Suppression Bursts Eiee Early Infantile Epileptic Encephalopathy With Suppression-Bursts Ohtahara Syndrome Encephalopathy, Epileptic, Early Infantile

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00278	ADAM22 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADAM22	RGD	RGD:1585016
Canis familiaris	ADAM22	VGNC	VGNC:37580
Felis catus	ADAM22	VGNC	VGNC:59580
Bos taurus	ADAM22	VGNC	VGNC:54401
Mus musculus	ADAM22	MGD	MGI:1340046
Macaca mulatta	ADAM22	VGNC	VGNC:69483
Others	ADAM22	NCBI