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SLCO1C1 - solute carrier organic anion transporter family member 1C1 Gene

Also Known as OATP1; OATPF; OATP-F; OATP14; OATP1C1; OATPRP5; SLC21A14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 53919

About SLCO1C1

Cytogenetic location: 12p12.2 Genomic coordinates (GRCh38): 12:20,695,332-20,753,386 (from NCBI)

This gene has 9 transcripts (splice variants), 256 orthologues and 10 paralogues. Biased expression in brain (RPKM 4.0), fat (RPKM 0.5) and 3 other tissues.

Summary

This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid Hormones in brain tissues. This protein has particularly high affinity for the thyroid Hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

SLCO1C1 Products (4)

mRNA	Protein	Name
NM_001145944.2	NP_001139416.1	solute carrier organic anion transporter family member 1C1 isoform 4
NM_001145945.2	NP_001139417.1	solute carrier organic anion transporter family member 1C1 isoform 3
NM_001145946.2	NP_001139418.1	solute carrier organic anion transporter family member 1C1 isoform 1
NM_017435.5	NP_059131.1	solute carrier organic anion transporter family member 1C1 isoform 2

SLCO1C1 Protein Structure

OATP

Kazal_2

0
200
400
600
712 a.a.

Protein Preferred Names	Protein Names
solute carrier organic anion transporter family member 1C1	OAT-RP-5

Related Diseases

Diseases	Alias
Allan-Herndon-Dudley Syndrome	AHDS Allan-Herndon Syndrome Monocarboxylate Transporter 8 Deficiency MCT8 DEFICIENCY Mental Retardation, X-Linked, With Hypotonia Triiodothyronine Resistance T3 Resistance Mental Retardation And Muscular Atrophy Mct8-Specific Thyroid Hormone Cell-Membrane Transporter Deficiency Intellectual Disability And Muscular Atrophy Monocarboxylate Transporter-8 Deficiency T3 Resisitence Triiodothyronine Resistence X-Linked Intellectual Disability With Hypotonia Mct8 -Specific Thyroid Hormone Cell Transporter Deficiency Monocarboxylate Transporter 8 Deficiency X-Linked Intellectual Disability-Hypotonia Syndrome
Deafness, Autosomal Recessive 62	DFNB62 Autosomal Recessive Nonsyndromic Deafness 62 Autosomal Recessive Deafness 62
Hyperthyroidism	Overactive Thyroid
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13354	SLCO1C1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLCO1C1	VGNC	VGNC:46494
Macaca mulatta	SLCO1C1	VGNC	VGNC:77697
Felis catus	SLCO1C1	VGNC	VGNC:65443
Rattus norvegicus	SLCO1C1	RGD	RGD:628660
Mus musculus	SLCO1C1	MGD	MGI:1889679
Bos taurus	SLCO1C1	VGNC	VGNC:34950