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POU3F1 - POU class 3 homeobox 1 Gene

Also Known as OCT6; OTF6; SCIP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5453

About POU3F1

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:38,043,829-38,046,793 (from NCBI)

This gene has 1 transcript (splice variant), 249 orthologues and 17 paralogues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of gene expression; and positive regulation of transcription, DNA-templated. Predicted to act upstream of or within keratinocyte differentiation; nervous system development; and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

POU3F1 Products (1)

mRNA	Protein	Name
NM_002699.4	NP_002690.3	POU domain, class 3, transcription factor 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9242494	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POU3F1 Protein Structure

Pou

Homeobox

0
100
200
300
400
451 a.a.

Protein Preferred Names	Protein Names
POU domain, class 3, transcription factor 1	OTF-6

Related Diseases

Diseases	Alias
Pyriform Sinus Cancer	Malignant Neoplasm Of Pyriform Fossa Malignant Neoplasm Of The Pyriform Fossa Malignant Tumor Of Pyriform Fossa
Scrotum Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Scrotum Scrotal Squamous Cell Carcinoma
Scrotal Carcinoma	Carcinoma Of Scrotum Malignant Neoplasm Of Scrotum Neoplasm Of Scrotum
Lymphocele	Lymph Cyst Lymphocele Adverse Event
Scrotum Neoplasm	Malignant Tumour Of Scrotum Malignant Scrotal Neoplasm Malignant Tumor Of Scrotum Neoplasm Of Scrotum Scrotal Ca Scrotal Tumor Scrotum Cancer Cancer Of Scrotum Malignant Neoplasm Of Scrotum Scrotal Cancer Malignant Scrotal Tumour Malignant Neoplasm Of Skin Of Scrotum Primary Malignant Neoplasm Of Scrotum
Schizophreniform Disorder	Schizophreniform Disorders Psychotic Disorders
Neurogenic Bowel
Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease	Pcwh Syndrome PCWH Neurologic Waardenburg-Shah Syndrome Waardenburg-Shah Syndrome, Neurologic Variant Peripheral Demyelinating Neuropathy-Central Dysmyelinating Leukodystrophy-Hirschsprung Disease-Waardenburg Syndrome Peripheral Demyelinating Neuropathy-Central Dysmyelinating Leukodystrophy-Waardenburg Syndrome-Hirschsprung Disease Ws4 Plus Peripheral Demyelinating Neuropathy, Central Dysmyelinating Leukodystrophy, Waardenburg Syndrome And Hirschsprung Disease Waardenburg-Shah Syndrome Neurologic Variant
Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive	Charcot-Marie-Tooth Disease Type 4 Charcot-Marie-Tooth Disease Type 4e Hereditary Motor And Sensory Neuropathy Cmt4e CHN1 Hypomyelinating Neuropathy, Congenital, 1 Charcot-Marie-Tooth Neuropathy Type 4e Neuropathy, Congenital Hypomyelinating, 1 Ar-Cmt1 Autosomal Recessive Demyelinating Charcot-Marie-Tooth Cmt4 Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive Hypomyelination, Severe Congenital Charcot-Marie-Tooth Disease, Type 4e Charcot-Marie-Tooth Neuropathy, Type 4e Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy Autosomal Recessive Congenital Hypomyelinating Neuropathy Congenital Amyelinating Neuropathy Congenital Hypomyelinating Neuropathy Autosomal Recessive Neuropathy, Congenital Hypomyelinating Or Amyelinating Severe Congenital Hypomyelination Hereditary Sensory Motor Neuropathy Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive Neuropathy, Hypomyelinating, Congenital, Type 1 Neuropathy, Motor And Sensory, Hereditary Congenital Hypomyelinating Neuropathy Hereditary Motor And Sensory Neuropathies Hereditary Sensorimotor Neuropathy Hmsn - [Hereditary Motor And Sensory Neuropathy] Hsmn - [Hereditary Sensory And Motor Neuropathy] Hereditary Motor And Sensory Neuropathy, Types I-Iv
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10900	POU3F1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	POU3F1	VGNC	VGNC:100045
Mus musculus	POU3F1	MGD	MGI:101896
Rattus norvegicus	POU3F1	RGD	RGD:619767
Canis familiaris	POU3F1	VGNC	VGNC:44829
Bos taurus	POU3F1	VGNC	VGNC:33176
Felis catus	POU3F1	VGNC	VGNC:107603
Others	POU3F1	NCBI